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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438887/
POLYMER THERAPEUTICS FOR DRUG DELIVERY. Polymer therapeutics is a term used to describe an increasingly important area of biopaharmaceutics in which a linear or branched polymer chain behaves either as the bioactive (a polymeric drug) or, more commonly, as the inert carrier to which a therapeutic is covalently linked, as in the case of polymer-drug conjugates, polymer-protein conjugates, polymeric micelles…Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://file.scirp.org/pdf/JBM_2016011414462012.pdf
Polymers in reservoir based drug delivery systems have shown immense progress in the form of hydrogels and liposomes. Diffusion based drug delivery systems (as shown in Figure 1) and solvent activated drug deliv- ery systems are the other areas being explored for utilizing the polymers [1].File Size: 1MB
https://www.mdpi.com/journal/polymers/special_issues/drug-delivery
These macromolecules are now being used in several drug delivery approaches (e.g., drug and protein conjugates, micro and nanoparticles, nanocapsules, matrices and hydrogels, polymersomes, complexing polymers etc.) or are themselves drugs (e.g., polymers for molecular sequestration).
https://www.mddionline.com/polymers-controlled-drug-delivery
Originally, polylactides and polyglycolides were used as absorbable suture material, and it was a natural step to work with these polymers in controlled drug delivery systems. The greatest advantage of these degradable polymers is that they are broken down into biologically acceptable molecules that are metabolized and removed from the body via normal metabolic pathways.
https://www.annualreviews.org/doi/abs/10.1146/annurev-chembioeng-073009-100847
Abstract. Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shelf materials, the field has grown tremendously,...Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://www.researchgate.net/publication/221876224_Polymers_for_Drug_Delivery_Systems
Polymers for Drug Delivery Systems. Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
https://www.ncbi.nlm.nih.gov/pubmed/22432577
Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery.Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://www.researchgate.net/profile/Subhashis_Debnath/publication/316590754_Polymers_used_in_the_Designing_of_Controlled_Drug_Delivery_System/links/5a1d20dc0f7e9b2a5316eb04/Polymers-used-in-the-Designing-of-Controlled-Drug-Delivery-System.pdf
Polymers are becoming very important in the drug delivery field. To control the drug release rate from the formulation, polymers are being used as the main tool.
https://www.frontiersin.org/articles/10.3389/fmats.2020.00073/full
Targeted and controlled drug delivery employing “smart materials” is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention. Thermo-responsive polymers have facilitated the formulation of in situ gel forming systems which undergo a sol-gel transition at physiological body temperature, and ...
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