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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084724/
Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called “sonoporation”), allowing for enhanced transport of therapeutic agents across these natural barriers.Author: Tzu-Yin Wang, Katheryne E. Wilson, Steven Machtaler, Jurgen K. Willmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · The presence of microbubbles in the insonified field reduces the peak negative pressure needed to enhance drug delivery with ultrasound. This occurs because the microbubbles act as nuclei for cavitation, decreasing the threshold of ultrasound energy necessary to …Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://www.sciencedirect.com/science/article/pii/S0169409X14000131
In addition to cavitation, another mechanism that is important in cardiovascular drug delivery with ultrasound is radiation force (see Fig. 3). Ultrasound creates a pushing force and will push microbubbles away from the transducer face.Author: Evan Unger, Thomas Richard Porter, Jonathan Lindner, Paul Grayburn
https://cardiovascularultrasound.biomedcentral.com/articles/10.1186/1476-7120-2-23
Nov 16, 2004 · Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials.
https://www.medgadget.com/2017/08/ultrasound-microbubbles-targeted-chemotherapy-delivery.html
Ultrasound and Microbubbles for Targeted Chemotherapy Delivery. Researchers in Norway have developed a chemotherapy delivery system consisting of microbubbles containing drug-loaded nanoparticles. When the researchers apply ultrasound to the microbubbles in a tumor, the microbubbles burst, releasing the nanoparticles and the chemotherapeutic drug.
https://www.sciencedirect.com/science/article/pii/S0168365914007342
While ultrasound is a well-established diagnostic imaging technique, its great potential in enhancing drug delivery was only acknowledged in the late 1990s . Since then, the ultrasound mediated uptake of small drugs [2] , proteins [3] , as well as larger nanoparticles such as gene complexes [4] or drug loaded liposomes [5] has been reported.Author: Ine De Cock, Elisa Zagato, Kevin Braeckmans, Ying Luan, Nico de Jong, Stefaan C. De Smedt, Ine Lenta...
https://www.cambridge.org/core/journals/journal-of-radiotherapy-in-practice/article/review-of-ultrasoundmediated-microbubbles-technology-for-cancer-therapy-a-vehicle-for-chemotherapeutic-drug-delivery/828C36D07CEB4C19F0238571DBBCDCB4
The unique behaviour of microbubbles under ultrasound acoustic pressure makes them useful agents for drug and gene delivery. Several studies have demonstrated the potential application of microbubbles as a non-invasive, safe and effective technique for targeted delivery of drugs and genes.
https://ultrasoundrepair.com/ultrasound-news/ultrasound-approach-monitors-drug-dose-delivery-location-in-brain
The novel method observes the behavior of microbubbles which aid in amplifying the effects of ultrasound waves as the microscopic bubbles open a contained spot in the BBB for targeted drug delivery, according to Randy King, Ph.D., director of the program in ultrasound at the National Institute of Biomedical Imaging and Bioengineering (NIBIB).
https://academic.oup.com/ehjcimaging/article/5/4/245/2367055
Aug 01, 2004 · These microbubbles can be used as a vehicle for drugs or genes and local delivery can be achieved by destruction of microbubbles with ultrasound. The same mechanism could be used in treatment of thrombo-embolic processes. Enhancement of thrombolysis with the use of microbubbles and ultrasound looks promising in vitro and in vivo.Author: P.A Dijkmans, L.J.M Juffermans, R.J.P Musters, A van Wamel, F.J ten Cate, W van Gilst, C.A Visser, N...
https://www.researchgate.net/publication/260194851_Cardiovascular_Drug_Delivery_with_Ultrasound_and_Microbubbles
The combination of the in vitro approach with ultrasound used to control microbubbles oscillations is expected to provide crucial information for developing cavitation enhanced drug delivery ...
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