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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084724/
Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called “sonoporation”), allowing for enhanced transport of therapeutic agents across these natural barriers.Author: Tzu-Yin Wang, Katheryne E. Wilson, Steven Machtaler, Jurgen K. Willmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · Mechanisms for Target Drug Delivery Using Microbubbles. Two possible strategies for delivering drugs and genes with microbubbles are emerging. The first consists on the ultrasound-mediated microbubble destruction, which is based on the cavitation of microbubbles induced by ultrasound application, and the second is the direct delivery of substances bound to microbubbles in …Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://www.sciencedirect.com/science/article/pii/S0168365914007342
1. Introduction. While ultrasound is a well-established diagnostic imaging technique, its great potential in enhancing drug delivery was only acknowledged in the late 1990s .Since then, the ultrasound mediated uptake of small drugs , proteins , as well as larger nanoparticles such as gene complexes or drug loaded liposomes has been reported. In these studies, ultrasound is often used in ...Author: Ine De Cock, Elisa Zagato, Kevin Braeckmans, Ying Luan, Nico de Jong, Stefaan C. De Smedt, Ine Lenta...
https://www.youtube.com/watch?v=Z6BMYNXbwLU
Oct 21, 2015 · Using ultrasound waves, researchers have found a way to enable rapid delivery of drugs to the gastrointestinal (GI) tract. This approach could make it …
https://jtultrasound.biomedcentral.com/articles/10.1186/2050-5736-1-10
Jul 01, 2013 · Ultrasound-targeted microbubble destruction (UTMD) is a promising technique for non-invasive, targeted drug delivery, and its applications in chemotherapeutic drug delivery to solid tumors have attracted growing interest. Ultrasound, which has been conventionally used for diagnostic imaging, has evolved as a promising tool for therapeutic applications mainly because of its ability to be ...Author: Hong Chen, Joo Ha Hwang
https://mbi-ctac.sites.medinfo.ufl.edu/files/2017/02/Ultrasound-microbubble-fundamentals-and-gene-delivery-Ferrara-et-al-2007.pdf
ties for drug delivery. Creation of a clinically optimized microbubble-based drug or gene delivery vehicle is challenging because there exists a vast parameter space of po-tential shell materials, targeting ligands, cargos, and ultrasound parameters. Herein, engineering analyses of both the microbubble shell and gas core are reviewed. As-
https://www.sciencedirect.com/science/article/pii/S0169409X14000131
It seems that microbubble and gene delivery technologies are converging, showing sufficient efficacy and benefit that some of these product candidates may enter clinical trials. 6.3. Conclusions. Cardiovascular drug delivery with ultrasound is a promising field with multiple potential applications.Author: Evan Unger, Thomas Richard Porter, Jonathan Lindner, Paul Grayburn
https://www.scintica.com/new-journal-article-ultrasound-induced-microbubble-cavitation-via-a-transcanal-or-transcranial-approach-facilitates-inner-ear-drug-delivery/
In a recent paper published in JCI Insight, researchers have demonstrated for the first time the feasibility of applying Ultrasound-induced Microbubble Cavitation via the external auditory canal as a technique to increase the efficiency of drug delivery to the inner ear.
https://cardiovascularultrasound.biomedcentral.com/articles/10.1186/1476-7120-2-23
Nov 16, 2004 · Ultrasound-mediated microbubbles destruction has been proposed as an innovative method for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of …
https://www.researchgate.net/publication/317589821_Ultrasound-guided_drug_delivery_in_cancer
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues ...
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