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https://link.springer.com/chapter/10.1007/978-94-007-2555-3_14
Nov 18, 2011 · Abstract. Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue.Author: Stuart Ibsen, Michael Benchimol, Dmitri Simberg, Sadik Esener
https://www.researchgate.net/publication/51815928_Ultrasound_Mediated_Localized_Drug_Delivery
Request PDF Ultrasound Mediated Localized Drug Delivery Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084724/
Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called “sonoporation”), allowing for enhanced transport of therapeutic agents across these natural barriers.Author: Tzu-Yin Wang, Katheryne E. Wilson, Steven Machtaler, Jurgen K. Willmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436072/
Jun 30, 2011 · From these beginnings, research on low-frequency ultrasound-mediated transdermal drug delivery has exploded, with dozens of different groups working on applications of this technology (see Table 2). All types of permeants, from small hydrophobic compounds, such as salicylic acid, to highly hydrophilic compounds, such as vasopressin, to proteins, such as insulin, and even vaccines or …Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.ncbi.nlm.nih.gov/pubmed/25367869
OBJECTIVE: To explore the antitumor effects of low-intensity focused ultrasound (LIFU) mediated localized drug delivery of adriamycin-microbubble-PLGA nanoparticle complexes on rabbits VX2 liver tumor. METHODS: ADM-NMCs were prepared by covalent linking of ADM-PLGA nanoparticles (ADM-NPs) to the shell of the microbubbles.Author: Yuping Gong, Zhigang Wang, Guifang Dong, Yang Sun, Xi Wang, Yue Rong, Maoping Li, Dong Wang, Haitao ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825174/
Oct 21, 2015 · The purpose of this study was to investigate the safety, tolerability, and utility of ultrasound-mediated drug delivery in the GI tract in tissue ex vivo as well as in vivo in Yorkshire pigs and mice. Low-frequency (<100 kHz) ultrasound was used and administered directly to GI tissue.Author: Carl M. Schoellhammer, Avi Schroeder, Avi Schroeder, Ruby Maa, Gregory Yves Lauwers, Albert Swiston,...
https://www.fusfoundation.org/mechanisms-of-action/drug-delivery-vehicles
Drug Delivery Vehicles Focused ultrasound can be used to release encapsulated drugs (e.g. genes, chemotherapeutics), delivering them in high concentrations to a …
https://stm.sciencemag.org/content/7/310/310ra168.full
Oct 21, 2015 · Ultrasound-mediated drug delivery could be used for other drugs, such as hydrocortisone, and even macromolecules, such as insulin, as demonstrated by the authors, thus serving as a simple physical solution to the barrier challenge in gastrointestinal drug delivery.Author: Carl M. Schoellhammer, Avi Schroeder, Avi Schroeder, Ruby Maa, Gregory Yves Lauwers, Albert Swiston,...
https://www.sciencedirect.com/science/article/pii/S0168365911000125
Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends ... (ii) at lower ultrasound frequencies, localized transport plays a more significant role, with LTRs observed on the surface of the skin, ... Usually, in LFS-mediated transdermal drug delivery experiments, 1% w/v SLS is used in the coupling medium.Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676802/
As with diagnostic ultrasound imaging, drug delivery using ultrasound requires a delicate balance between safety and efficacy and requires careful scientific study. Other recent reviews on drug delivery state similar views to those expressed here, for example, “small-sized low-frequency transducers need to be developed so that patients can wear them” ( Pitt et al 2004 ).Author: Nadine Barrie Smith
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