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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516840/
Nov 08, 2012 · Ultrasound (US)-mediated gene delivery (UMGD) is emerging as a promising noninvasive and non-viral strategy for gene therapy 1, 2. In contrast to viral vectors, which bear the risk of immunotoxicity, insertional mutagenesis, and nonspecific gene delivery 3 , UMGD is considered to be a safer approach which provides remarkable spatial and temporal control of gene transfer 4 .Author: Cedric M. Panje, David S. Wang, Marybeth A. Pysz, Ramasamy Paulmurugan, Ying Ren, Francois Tranquart...
https://www.nature.com/articles/s41596-019-0125-y
Feb 25, 2019 · Ultrasound-mediated gene delivery (sonoporation) is a minimally invasive, nonviral and clinically translatable method of gene therapy. This method offers a favorable safety profile over that of viral vectors and is less invasive as compared with other physical gene delivery …Author: Maxim Bez, Maxim Bez, Josquin Foiret, Galina Shapiro, Gadi Pelled, Katherine W. Ferrara, Dan Gazit
https://www.sciencedirect.com/science/article/pii/S0168365905000295
Previous work from other groups suggests that ultrasound-mediated gene delivery could be due to an enhancement of membrane permeability, probably by the formation of pores in the cell membrane. However, the plasmid internalization and its intracellular trafficking in …Author: Sophie Mehier-Humbert, Thierry Bettinger, Feng Yan, Richard H. Guy, Richard H. Guy
https://www.researchgate.net/publication/221919217_Ultrasound-Mediated_Gene_Delivery
Ultrasound-Mediated Gene Delivery 219 Optison and Sonazoid were equivalent in effectiveness, producing about four times greater expression than did SonoVue {Alter et al. 2009}.
http://www.thno.org/v04p1133.htm
Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System . Young Il Yoon 1,2,3 *, Yong-Su Kwon 4 *, Hee-Sang Cho 4, Sun-Hee Heo 5, Kyeong Soon Park 5, Sang Gyu Park 5, Soo-Hong Lee 5, Seung Il Hwang 1,2, Young Il Kim 1, Hwan Jun Jae 1, Gook-Jun Ahn 7, Young-Seok Cho 8, Hakho Lee 9 , Hak Jong Lee 1,2,3,10 , Tae-Jong Yoon 4 . 1.
https://www.researchgate.net/publication/41485509_Ultrasound-mediated_gene_delivery
Ultrasound-mediated gene delivery can be accomplished within 10 min. After DNA delivery, animals can be followed to monitor gene expression, protein secretion and other transgene-specific outcomes ...
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