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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504014/
Jun 30, 2008 · 3.3.6. Gene delivery to the brain . Gene therapy could have significant potential in the treatment of various CNS diseases but the delivery into the brain is limited by the large size of the agents. It is likely that the focused ultrasound method could be used to deliver gene vectors through the BBB.Author: Kullervo Hynynen
https://www.ncbi.nlm.nih.gov/pubmed/18486271
Jun 30, 2008 · Ultrasound for drug and gene delivery to the brain. Hynynen K(1). ... The combination of focused ultrasound beams with MR image guidance allows precise anatomical targeting as demonstrated by the delivery of several marker molecules in different animal models. This method may in the future have a significant impact on the diagnosis and ...Author: Kullervo Hynynen
https://www.sciencedirect.com/science/article/pii/S0169409X08000859
3.3.6. Gene delivery to the brain. Gene therapy could have significant potential in the treatment of various CNS diseases but the delivery into the brain is limited by the large size of the agents. It is likely that the focused ultrasound method could be used to deliver gene vectors through the BBB.Author: Kullervo Hynynen
http://med.stanford.edu/news/all-news/2018/11/ultrasound-releases-drug-to-alter-activity-in-targeted-brain-area.html
But having crossed this barrier, the drug is quickly soaked up by brain tissue, so that it never gets farther than about a half-millimeter from the capillary where it’s been released. Airan and his colleagues injected these particles intravenously into rats and explored focused …
https://www.sciencedirect.com/science/article/pii/B9780124077225000165
Drug and Gene Delivery to the Brain 278. Drug and Gene Delivery to the Lungs 279. Gene Therapy for Specific Applications 279. Bioactive Gas for Specific Applications 280. Potential Pitfalls in Ultrasound-Mediated Delivery into Tumor Tissue 280. Conclusions 280. Acknowledgments 280. References 281Author: Shao-Ling Huang, David D. McPherson
https://www.nature.com/naturecareers/job/postdoctoral-research-associate-position-in-ultrasoundmediated-drug-and-gene-delivery-research-and-ultrasound-bioeffects-university-of-pittsburgh-school-of-medicine-upsom-719271
Postdoctoral Research Associate Position in Ultrasound-mediated Drug and Gene Delivery Research and Ultrasound Bioeffects, with University of Pittsburgh School of Medicine (UPSOM). Apply Today.Work Location: PA
https://www.sciencedaily.com/releases/2018/11/181107111850.htm
Nov 07, 2018 · Scientists have developed a noninvasive way of delivering drugs to within a few millimeters of a desired point in the brain. The method, tested in …
https://www.researchgate.net/publication/317589821_Ultrasound-guided_drug_delivery_in_cancer
Ultrasound-guided drug delivery in cancer. ... ultrasound for drug delivery to brain tumors: current progress and ... fundamentals and application to gene and drug delivery.
http://www.fusfoundation.org/images/pdf/Drug-and-gene-delivery-across-bbb.pdf
preventing drug delivery to the brain. 1.2. Conventional approaches for bypassing the blood–brain barrier Given the central role of the BBB in limiting drug and gene delivery to the CNS, numerous methods have been developed to bypass this Table 1 Key references demonstrating drug or …Author: Kelsie F. Timbie, Brian P. Mead, Richard J. Price
https://pubs.acs.org/doi/abs/10.1021/cn300191b
Brain diseases are notoriously difficult to treat due to the presence of the blood-brain barrier (BBB). Here, we review the development of focused ultrasound (FUS) as a noninvasive method for BBB disruption, aiding in drug delivery to the brain. FUS can be applied through the skull to a targeted region in the brain. When combined with microbubbles, FUS causes localized and reversible ...Author: Alison Burgess, Kullervo Hynynen
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