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https://www.sciencedirect.com/science/article/pii/S0168365904001579
Tumor-targeted gene delivery is a promising strategy for enhancing the efficacy of cancer gene therapy . The main objective of the present study was to investigate the utility of trastuzumab–PEI conjugates (HerPEI) as targeted gene delivery vectors.Author: Shih Jiuan Chiu, Naoto T. Ueno, Robert J. Lee
https://tmu.pure.elsevier.com/en/publications/tumor-targeted-gene-delivery-via-anti-her2-antibody-trastuzumab-h
Jun 18, 2004 · title = "Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin{\circledR}) conjugated polyethylenimine", abstract = "A series of novel nonviral vectors targeting the HER-2/neu gene product human epidermal growth factor receptor-2 (HER2) were constructed and evaluated in breast cancer cell lines to optimize vector formulation for receptor-specific gene transfer.Author: Shih Jiuan Chiu, Naoto T. Ueno, Robert J. Lee
https://mdanderson.elsevierpure.com/en/publications/tumor-targeted-gene-delivery-via-anti-her2-antibody-trastuzumab-h
title = "Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin{\circledR}) conjugated polyethylenimine", abstract = "A series of novel nonviral vectors targeting the HER-2/neu gene product human epidermal growth factor receptor-2 (HER2) were constructed and evaluated in breast cancer cell lines to optimize vector formulation for receptor-specific gene transfer.Author: Shih Jiuan Chiu, Naoto T. Ueno, Robert J. Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946976/
Targeted delivery of genes to cancer cells has been achieved in a limited number of laboratories using liposomal delivery systems with antibody to human epidermal growth factor receptor 2 (Her2) receptors, 1, 2 with an RGD peptide specific for integrin, 3 or with antibody to prostate-specific membrane antigen…Author: K Mann, M Kullberg
https://www.researchgate.net/publication/8510345_Tumor-targeted_gene_delivery_via_anti-HER2_antibody_trastuzumab_Herceptin_R_conjugated_polyethylemmine
In summary, HerPEI polyplexes have shown promising HER2 receptor-specific gene transfer properties and warrant further evaluation as a tumor-targeted vector for gene therapy.
https://www.nature.com/articles/cgt201621
May 20, 2016 · Trastuzumab is responsible for specific targeting of Her2 receptors and uptake of the gene delivery complex into endosomes of recipient cells, …Author: K Mann, M Kullberg
https://journals.sagepub.com/doi/abs/10.1177/0883911518813677
Nov 21, 2018 · To combine the targeted gene delivery and cell-specific transcriptional targeting, a delivery system was designed based on Generation 5 polyamidoamine dendrimer (PAMAM), poly (ethylene glycol), and anti-HER2 (human epidermal growth factor receptor 2) variable domains of camelid heavy chain antibodies (single domain antibody, VHHs).Author: Farnoush Jafari Iri Sofla, Fatemeh Rahbarizadeh, Davoud Ahmadvand, Alireza Nomani, Erik Vernet
https://www.sciencedirect.com/science/article/pii/S0168365908000643
Apr 21, 2008 · G250 is a tumor associated antigen that is found on > 90% of renal cell carcinoma (RCC). In order to develop a highly targeting gene vector for RCC gene therapy, G250 monoclonal antibody was prepared, purified and characterized. The antibody was chemically bound to Polyethylenimine (PEI) to form the IgG–PEI conjugate.Author: Yajun Duan, Junnian Zheng, Sufang Han, Yi Wu, Yanming Wang, Deguan Li, Deling Kong, Yaoting Yu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: Crossing the blood-brain-barrier divide Ann-Marie Chacko , 1, 5 Chunsheng Li , 2 Daniel A. Pryma , 1 Steven Brem , 3, 4 George Coukos , 2 and Vladimir R. Muzykantov 5Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191406/
Oct 13, 2014 · Delivery of the cRGD-siRNAs to the tumors resulted in the specific and effective down-regulation of targeted genes (Figure (Figure4). 4). Finally, we showed that down-regulation of VEGFR2 (one of the genes known to be required for angiogenesis) in mouse tumors resulted in reduced blood vessel formation and substantially slower tumor growth (Figure (Figure5). 5 ).Author: Xiaoxia Liu, Wei Wang, Dmitry Samarsky, Li Liu, Qian Xu, Wenqing Zhang, Guangzu Zhu, Ping Wu, Xialin...
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