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https://www.sciencedirect.com/science/article/pii/S1350946201000180
In vitro and in vivo studies suggest that the transscleral route may offer a means to achieve the goal of sustained, targeted drug delivery to the posterior segment. Potentially therapeutic concentrations of macromolecules with retention of bioactivity can be attained in the choroid and retina via minimally invasive transscleral delivery.Author: Jayakrishna Ambati, Jayakrishna Ambati, Anthony P Adamis, Anthony P Adamis
https://www.ncbi.nlm.nih.gov/pubmed/12062532
In vitro and in vivo studies suggest that the transscleral route may offer a means to achieve the goal of sustained, targeted drug delivery to the posterior segment. Potentially therapeutic concentrations of macromolecules with retention of bioactivity can be attained in the choroid and retina via minimally invasive transscleral delivery. PMID:Author: Jayakrishna Ambati, Jayakrishna Ambati, Anthony P Adamis, Anthony P Adamis
https://www.researchgate.net/publication/11311052_Transscleral_Drug_Delivery_to_the_Retina_and_Choroid
Transscleral drug delivery is one of the methods of depositing drug in the posterior segment (comprising retina, choroid, sclera and macula) of the human eye, to treat diseases such as age related ...
https://www.ncbi.nlm.nih.gov/pubmed/17069929
Nov 15, 2006 · Although it is possible to deliver drugs from a subconjunctival drug depot to the retina and choroid, the barriers and kinetics of this route of drug administration are not well known. In this review we investigate the pharmacokinetic aspects of transscleral drug delivery into the posterior eye with emphasis on pharmacokinetic modeling ...Author: Veli-Pekka Ranta, Arto Urtti
https://www.sciencedirect.com/science/article/pii/S001793101200381X
Transscleral drug delivery is one of the methods of depositing drug in the posterior segment (comprising retina, choroid, sclera and macula) of the human eye, to treat diseases such as age related macular degeneration (AMD).Author: Arunn Narasimhan, Ramanathan Vishnampet
https://www.deepdyve.com/lp/elsevier/transscleral-drug-delivery-to-the-retina-and-choroid-9fWA7o4YaO
Mar 01, 2002 · Transscleral drug delivery to the retina and choroid Transscleral drug delivery to the retina and choroid Ambati, Jayakrishna; Adamis, Anthony P 2002-03-01 00:00:00 Rapid advances in the molecular pathogenesis of retinal and choroidal disorders have highlighted the urgent need for innovative drug delivery modalities to the loci of pathology.
https://www.researchgate.net/publication/12563347_Transcleral_delivery_of_bioactive_protein_to_the_choroid_and_retina
To investigate the feasibility of transscleral drug delivery to the choroid and retina. An osmotic pump was used to deliver IgG across the sclera of pigmented rabbits, and levels were measured in ...
http://www.freepatentsonline.com/y2005/0208103.html
Sep 22, 2005 · The invention provides methods for delivering a therapeutic or diagnostic agent to the eye of a mammal. The method involves contacting sclera with a …
https://drum.lib.umd.edu/bitstream/handle/1903/3609/umi-umd-3457.pdf;sequence=1
[5] [8] [9]. Transscleral drug delivery to posterior segment targets have been investigated because the sclera is significantly more permeable than the cornea [4]. Choroid The choroid is a thin vascular tissue that lines the inner surface of the sclera. It extends from the optic nerve posteriorly to the ciliary body anteriorly, where it
https://www.crcpress.com/Ocular-Drug-Delivery-Systems-Barriers-and-Application-of-Nanoparticulate/Thassu-Chader/p/book/9781439848005
Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause seri
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