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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627589/
Jun 25, 2019 · Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this review, a classification of current approaches of clinical or investigational importance for the delivery of therapeutics to the CNS is presented. ... Transporter-Mediated Transcytosis ...Author: Rana Abdul Razzak, Gordon John Florence, Francis James Gunn-Moore
https://www.sciencedirect.com/science/article/pii/S1359644604031988
A schematic of transporter-mediated oral delivery and disposition of drugs. Although several drug transporters can be used as novel delivery systems (shown in black), transport mechanisms for the majority of drugs are still unknown (shown in red).Author: Yoshimichi Sai, Akira Tsuji
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361857/
Oct 24, 2018 · In this paper, we reviewed the recent developments in transporter-targeted nano-DDS on the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery, transporter-assisted brain-targeting nano-DDS, transporter-mediated tumor-targeting drug delivery, and the specific transport mechanisms involved in the transporter ...Author: Hongyan Su, Yan Wang, Shuo Liu, Yue Wang, Qian Liu, Guangxuan Liu, Qin Chen
https://www.sciencedirect.com/science/article/pii/S0378517320301046
The aim was to explore the potential applications of bile acid transporter mediated the self-assembled hybrid nanoparticles (SHNPs) of sodium taurocholate (STC) and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) for augmenting the oral delivery of poorly water-soluble drugs. Felodipine (FLDP) was chosen as a model drug.Author: Shujuan Zhang, Dongmei Cui, Jiawei Xu, Jiandong Wang, Qi Wei, Subin Xiong
https://www.fda.gov/media/78640/download
Delivery to site of action ... Examples of Transporter-Mediated Drug Interactions. 5. Which transporters are clinically important and should be considered for evaluation during drug
https://www.mdpi.com/1999-4923/12/2/154/htm
There are multiple preclinical studies that have described neuroprotective effects of memantine, as it is the prototypic transporter mediated neuroprotective drug. Studying the transporter mechanisms of memantine will undoubtably influence structure-based design for similar drugs with this desired mechanism of action.Author: Erica I. Williams, Robert D. Betterton, Thomas P. Davis, Patrick T. Ronaldson
https://www.medscape.com/viewarticle/754318_2
Nov 09, 2019 · Transporter-mediated drug–drug interactions may also have beneficial effects. For example, the tolerability of cytotoxic drugs may be reduced by the inhibition of …
https://www.mdpi.com/1422-0067/20/12/3108/htm
The most attractive attribute of drug delivery facilitated by AMT is that it does not interfere with endogenous cellular functions the way CMT or RMT-mediated drug delivery do. To date, there are no records, to our knowledge, that can demonstrate an interference of AMT with cellular signaling pathways.Author: Rana Abdul Razzak, Gordon John Florence, Francis James Gunn-Moore
http://ors.umkc.edu/otc/technologies/drug-delivery-that-overcomes-p-glycoprotein-mediated-drug-efflux
Dr ug Delivery that Overcomes P-Glycoprotein Mediated Drug Efflux. A drug delivery system that overcomes the problems associated with P-glycoprotein mediated drug efflux. Disadvantages of Current Treatments: P-Glycoprotein (P-gp) is a transport protein that effluxes a wide variety of structurally unrelated drugs out of cells.
https://www.frontiersin.org/articles/10.3389/fphar.2018.00027/full
Jan 26, 2018 · Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and therapy. Transporters are expressed differentially on the cell-surface of different cell types, and also specific transporters are expressed at higher than normal levels in selective cell types under pathological ...Author: Longfa Kou, Longfa Kou, Yangzom D. Bhutia, Qing Yao, Zhonggui He, Jin Sun, Vadivel Ganapathy
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