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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal delivery has a variety of advantages compared with the oral route. In particular, it is used when there is a significant first-pass effect of the liver that can prematurely metabolize drugs. Transdermal delivery also has advantages over hypodermic injections, which are painful, generate ...Author: Mark R Prausnitz, Robert Langer
https://www.sciencedirect.com/topics/nursing-and-health-professions/transdermal-drug-delivery-system
The transdermal drug delivery system is a technique that provides drug absorption via the skin. The system has many advantages over conventional administration routes such as intravenous or oral administration for systemic and local drug delivery with simple administration.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
In general, it seems that a transdermal delivery system for insulin is an attractive option. Even though progress in the transdermal delivery of insulin seems promising, because of the poor permeation capacity of insulin and the high susceptibility of the skin to adverse immunological reactions, it is still doubtful whether this delivery route ...
https://www.researchgate.net/publication/270015915_Transdermal_drug_delivery_system_An_overview
Transdermal drug delivery system (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through the skin in a predetermined and ...
http://ijpsr.com/bft-article/transdermal-drug-delivery-system-a-review/?view=fulltext
12.2 Polymer matrix: Polymers are the backbone of transdermal drug delivery system. System for transdermal delivery are fabricated as multi layered polymeric laminates in ehich a drug reservoir or a drug polymer matrix is sandwitched between two polymeric layers, an outer impervious backing layer that prevents the loss of drug through the backing surface and an inner polymeric layer that ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5].The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://medical-dictionary.thefreedictionary.com/transdermal+drug+delivery
Transdermal drug delivery has some benefits: skipping first pass metabolism in liver, steady infusion of a drug over an extended period of time, better compliance of the patient due to ease of usage and reduced frequency of use, a choice for drugs with low therapeutic index and short half life, and so easy elimination of drug when toxicity occurs during the application [3,5,6].
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