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https://www.sciencedirect.com/science/article/pii/S0928493109002094
Drug delivery systems developed for local delivery of antibiotics can be divided into nonbiodegradable and biodegradable carriers . Nonbiodegradable delivery systems such as polymethylmethacrylate (PMMA) beads containing gentamicin have been approved for use in treatment of osteomyelitis in Europe , . This product has been proven to be ...Author: Samit Kumar Nandi, Prasenjit Mukherjee, Subhasis Roy, Biswanath Kundu, Dipak Kumar De, Debabrata Bas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884906/
The local delivery of antibiotics in the treatment of osteomyelitis has been used safely and effectively for decades. Multiple methods of drug delivery have been developed for the purposes of both infection treatment and prophylaxis. The mainstay of treatment ...Author: Jaspaul S. Gogia, John P. Meehan, Paul E. Di Cesare, Amir A. Jamali
https://www.researchgate.net/publication/248281481_Local_antibiotic_delivery_systems_for_the_treatment_of_osteomyelitis_-_A_review
Local antibiotic delivery systems for the treatment of osteomyelitis – A review Article in Materials Science and Engineering C 29(8):2478-2485 · October 2009 with 411 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/abs/pii/S0928493109002094
Local antibiotic delivery systems for the treatment of osteomyelitis – A review ... Local drug delivery for osteomyelitis is a topic of importance for more than 20 years. Carrier materials used for local delivery of antibiotics may be classified as nonbiodegradable and biodegradable. Commonly used non biodegradable carrier materials are ...Author: Samit Kumar Nandi, Prasenjit Mukherjee, Subhasis Roy, Biswanath Kundu, Dipak Kumar De, Debabrata Bas...
https://journals.sagepub.com/doi/abs/10.1177/1534734614566937
In patients with diabetes mellitus, osteomyelitis is a severe, difficult-to-treat form of foot infection. In the management of diabetic foot osteomyelitis, carriers for local delivery of antimicrobial agents have begun to be tried, in an attempt to provide high local antibiotic concentrations.Author: Periklis Panagopoulos, Georgios Drosos, Efstratios Maltezos, Nikolaos Papanas
https://journals.sagepub.com/doi/pdf/10.1177/1534734618757532
osteomyelitis, antibiotic carriers +/− diabetic foot infections or diabetic foot osteomyelitis. Classes of Local Antibiotic Delivery Systems and Pharmacokinetic Properties Much of the provenance of topical antibiotic therapies origi-nates from orthopedic-driven interventions. Local antibiotic
https://www.researchgate.net/publication/44692184_Local_Antibiotic_Therapy_in_Osteomyelitis
Local antibiotic delivery in osteomyelitis treatment has been studied for years. Poly(methyl methacrylate) is the most widely used polymer for antibiotic delivery in orthopedic infection (Gogia ...
https://www.ncbi.nlm.nih.gov/pubmed/29458291
The local application of antibiotics is an emerging field in the treatment of diabetic foot infections, with demonstrable advantages. These include delivery of high concentrations of antibiotics in the affected area, limited systemic absorption, and thus negligible side effects.Author: Konstantinos Markakis, Alan Robert Faris, Hamed Sharaf, Barzo Faris, Sharon Rees, Frank L. Bowling
https://journals.lww.com/clinorthop/Pages/articleviewer.aspx?year=2004&issue=10000&article=00016&type=Fulltext
Local antibiotic therapy, by achieving high local antibiotic concentrations without systemic toxicity, seems to be a safe and useful adjunct in the management of open fractures and osteomyelitis. Randomized control trials are needed to provide high-quality evidence on the exact role of local antibiotic therapy in controlling infection.
https://cdn.intechopen.com/pdfs/26559/InTech-Local_antibiotic_therapy_in_the_treatment_of_bone_and_soft_tissue_infections.pdf
The delivery of local antibiotics for the treatment of musculoskeletal infection has become increasingly popular for a variety of reasons. The basis for developing and using local antibiotic delivery systems in the treatment of bone and soft tissue infection is either to …
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