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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
Transdermal delivery of peptides and proteins is a promising alternative to conventional parenteral delivery. Enhancement techniques such as microporation, iontophoresis, or sonophoresis help bypass penetration barriers of the skin and enable the delivery of hydrophilic molecules and macromolecules.
https://link.springer.com/article/10.1208%2Fs12249-011-9601-6
Mar 03, 2011 · Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternativ Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules.Author: Haripriya Kalluri, Ajay K. Banga
https://www.nature.com/articles/nbt1193
Mar 26, 2006 · Transdermal protein delivery by a coadministered peptide identified via phage display. Abstract. Efficient transdermal drug delivery of large hydrophilic drugs is challenging. Here we report that the short synthetic peptide, ACSSSPSKHCG, identified by in vivo phage display, facilitated efficient transdermal protein drug delivery through intact skin.Author: Yongping Chen, Yuanyuan Shen, Xin Guo, Caoshou Zhang, Wenjuan Yang, Minglu Ma, Shu Liu, Maobin Zhang...
https://science.sciencemag.org/content/269/5225/850
Aug 11, 1995 · Transdermal drug delivery offers a potential method of drug administration. However, its application has been limited to a few low molecular weight compounds because of the extremely low permeability of human skin.Author: S Mitragotri, D Blankschtein, R Langer
https://www.sciencedirect.com/science/article/pii/S0169409X18300231
Transdermal drug delivery offers a clinical superiority over traditional, invasive injections. As compared to oral delivery, protein drug transportation across the skin avoids the hepatic first-pass extraction and is delivered to the systematic circulation at a pharmacologically relevant rate [1, 2].Author: Yanqi Ye, Jicheng Yu, Di Wen, Anna R. Kahkoska, Zhen Gu
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201601411
Mar 24, 2017 · Transdermal delivery of therapeutic proteins and peptides is challenging due to very low permeability of these macromolecules across the skin. Traditionally, various physical enhancement techniques have been used to address the delivery challenge.Author: Amrita Banerjee, Kelly Ibsen, Yasunori Iwao, Michael Zakrewsky, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.nature.com/articles/srep26278
May 18, 2016 · In this context, transdermal delivery of therapeutics using cell-penetrating peptides (CPPs) is an attractive and novel approach 11. CPPs constitute a family of small peptides, which have an inherent ability to traverse biological membrane without causing significant membrane damage 13,14,15.Author: Ankur Gautam, Jagpreet Singh Nanda, Jesse S. Samuel, Manisha Kumari, Priyanka Priyanka, Gursimran Be...
https://www.dovepress.com/promotion-of-the-transdermal-delivery-of-protein-drugs-by-n-trimethyl--peer-reviewed-fulltext-article-IJN
Transdermal delivery of protein drugs is very attractive. However, the permeability of skin to protein drugs is extremely low because of the formidable barrier function of the SC. Currently, a variety of NPs, physical methods and penetration enhancers have been used to enhance the transdermal delivery of protein drugs.Author: Ye Tu, Xinxia Wang, Ying Lu, He Zhang, Yuan Yu, Yan Chen, Junjie Liu, Zhiguo Sun, Lili Cui, Jing Gao...
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