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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Traditionally, microdermabrasion is used to lessen the appearance of fine lines, wrinkles, and scars (15, 16). In recent years, microdermabrasion has been used as a method of disrupting the stratum corneum for transdermal drug delivery (17 – 20). In this study, we used microdermabrasion to address two related topics.Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pubmed/21499837
PURPOSE: Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin's barrier properties prevent insulin permeation at useful levels.Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://link.springer.com/article/10.1007/s11095-011-0435-4
Apr 16, 2011 · Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes. However, skin’ We investigated whether microdermabrasion can selectively remove skin’s surface layers to increase skin permeability as a method to administer insulin to diabetic rats.Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://www.researchgate.net/publication/51057666_Transdermal_Insulin_Delivery_Using_Microdermabrasion
Transdermal insulin delivery is an attractive needle-free alternative to subcutaneous injection conventionally used to treat diabetes.
http://drugdelivery.chbe.gatech.edu/Papers/2011/Andrews%20Pharm%20Res%202011.pdf
Traditionally, microdermabrasion is used to lessen the appearance of fine lines, wrinkles, and scars (15,16). In recent years, microdermabrasion has been used as a method of disrupting the stratum corneum for transdermal drug delivery (17–20). In this study, we used microdermabrasion to address two related topics.
https://www.deepdyve.com/lp/springer-journals/transdermal-insulin-delivery-using-microdermabrasion-TOjJCSXMIq
Apr 16, 2011 · Transdermal Insulin Delivery Using Microdermabrasion Viable epidermis is a barrier to insulin delivery such that removal of full epidermis enables significantly more insulin delivery than removal of stratum corneum alone.
https://diabetestalk.net/insulin/transdermal-insulin-delivery-system
Apr 12, 2018 · Transdermal Insulin Delivery. One of the skin's primary roles is to provide protection against infection and physical damage. This barrier is so effective that it prevents many pharmaceutical compounds from crossing into the bloodstream.
https://www.sciencedirect.com/science/article/pii/S0169409X18303090
Jet injection is another needle-free administration for transdermal insulin delivery. Instead of solid syringes, the jet injector applies a high-speed narrow stream containing insulin to create a tiny hole for insulin transport through the skin [[135], [136], [137]].Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/transdermal-insulin-delivery/
Vyteris transdermal drug delivery uses an iontophoretic delivery technology that delivers drugs comfortably through the skin using low-level electrical energy. This technology is claimed to allow precise dosing, with control of the rate, dosage, and pattern of drug delivery.
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