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https://www.tandfonline.com/doi/abs/10.3109/03639048809151970
The advantages of delivering drugs across the skin for systemic therapy are well documented (1-6), and transdermal drug delivery, on its own merits, has now become one of the fastest growing areas in drug development. The limitations and constraints of this mode of drug …Author: Donald C. Monkhouse, Abu S. Huq
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5]. The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
https://www.pharmacytimes.com/publications/issue/2013/may2013/transdermal-drug-delivery-systems-the-skinny-on-cutaneous-reactions
Transdermal drug delivery systems have grown in popularity, but side effects that include dermatitis and contact allergic reactions are possible. News Clinical Focus
https://academic.oup.com/bjaed/article/7/5/171/535087
Oct 01, 2007 · Opioid transdermal drug delivery systems The transdermal delivery of opioids provides some advantages. It avoids the peaks and troughs of intermittent dosage regimens that can lead to side-effects such as sedation, nausea and vomiting, and respiratory depression.Author: Lyn Margetts, Richard Sawyer
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
Introduction: The most conventional drug delivery systems exist with limitations such as drug degradation, toxicity and low bioavailability. Also, hypodermic injections can cause pain, compromising patient compliance. Due to this, transdermal drug delivery systems (TDDS) can minimize several problems associated with conventional drug delivery.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
One of the limitations of transdermal drug–delivery systems is the limitation in the number of drugs that can pass through the skin due to its low permeability.
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