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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs.Author: Mark R Prausnitz, Robert Langer
https://www.sciencedirect.com/science/article/pii/S0169409X17301801
(d) Third generation transdermal drug delivery technology for enhanced drug transport via microneedle-mediated destruction of skin layer and various functionalities accompanying microneedles. (e) Fourth generation transdermal drug delivery technology for patient-customized therapy with the assistance of wearable devices.Author: Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794664/
Oct 14, 2019 · Coated MNs . Coated MNs are used for transdermal drug delivery based on the “coat-and-poke” manner. Specifically, MNs coated with drug formulation are inserted into the skin, then the drugs dissolve from the MNs and enter into the skin, and finally MNs are pulled out of the skin, 29,34,35 as shown in Figure 1B.This approach is simple because it just takes one step to deliver the drug ...
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
The development of microneedle (MNs) arrays is an approach which allows drug delivery through the skin by improving safety, efficacy and bioavailability. Hence, several studies have been searching for new ways of treatment using microneedle devices for transdermal drug delivery.
https://www.sciencedirect.com/science/article/pii/0738081X89900047
3 Transdermal Drug Delivery Devices Philip W. Ledger, PhD. and Kirstin C. Nichols, MA From ALZA Corporation, Palo Alto, California The concept of transdermal delivery is not new, but until recently, its therapeutic application was restricted to creams and ointments which are messy and difficult to apply uniformly to ensure reproducible dosing.Author: Philip W. Ledger, Kirstin C. Nichols
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