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https://www.nature.com/articles/nbt1195-1205
To increase transport of a highly-charged macromolecule (heparin), high-voltage pulses believed to cause electroporation were applied to skin. Using this approach, transdermal heparin transport ...Author: Prausnitz Mr, Prausnitz Mr, Edelman Er, Edelman Er, Gimm Ja, Langer R, Weaver Jc
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810085/
Mar 17, 2016 · Electroporation-mediated transdermal delivery of selected compounds across different skin models is shown in Table 1. Blagus et al. used a new in vivo real-time monitoring system based on fluorescently labeled molecules for the quantification of transdermal and topical drug delivery [ 18 ].Author: Kevin B. Ita
https://reference.medscape.com/medline/abstract/9636293
Transdermal delivery would be an attractive solution, except macromolecules have not previously been delivered clinically across human skin at therapeutic rates. To increase transport of a highly-charged macromolecule (heparin), high-voltage pulses believed to cause electroporation were applied to skin.
https://www.sciencedirect.com/science/article/pii/S0169409X03002436
Electroporation is the transitory structural perturbation of lipid bilayer membranes due to the application of high voltage pulses. Its application to the skin has been shown to increase transdermal drug delivery by several orders of magnitude.Author: Anne-Rose Denet, Rita Vanbever, Véronique Préat
https://www.researchgate.net/publication/12600465_Transdermal_Delivery_of_Macromolecules_Using_Skin_Electroporation
(1) To evaluate the feasibility of transdermal delivery of macromolecules by skin electroporation. (2) To assess the influence of the molecular weight of the permeant on transport and examine ...
https://www.sciencedirect.com/science/article/pii/S0378517315303690
1.2. Electroporation-assisted delivery of heparin. Transdermal electroporation, which is also called electropermeabilization, takes place when the skin is exposed to high electric field pulses (García-Sánchez et al., 2015). Molecules are able to cross the stratum corneum when the optimal electroporation parameters are chosen.Author: Kevin Ita
https://www.ncbi.nlm.nih.gov/pubmed/15019751
Mar 27, 2004 · Electroporation is the transitory structural perturbation of lipid bilayer membranes due to the application of high voltage pulses. Its application to the skin has been shown to increase transdermal drug delivery by several orders of magnitude.Author: Anne-Rose Denet, Rita Vanbever, Véronique Préat
https://www.researchgate.net/publication/43200076_Enhancement_of_Transdermal_Delivery_of_Heparin_by_Various_Physical_and_Chemical_Enhancement_Techniques
This review focuses on the transdermal delivery of LMWH, providing a brief overview of heparin delivery via invasive and oral routes and discusses the advantages of using LMWH rather than heparin ...
http://drugdelivery.chbe.gatech.edu/Papers/1997/Weaver%20Biochem%20Biophys%20Res%20Comm%201997.pdf
Heparin Alters Transdermal Transport Associated with Electroporation ... results support the skin electroporation hypothesis solution.4,6,7 and provide the first demonstration of a chemical en-Heparin and fluorescent tracer molecules. ... transdermal drug delivery, ...
https://link.springer.com/chapter/10.1007/978-3-662-53273-7_7
May 05, 2017 · Prausnitz MR, Edelman ER, Gimm JA, Langer R, Weaver JC (1995) Transdermal delivery of heparin by skin electroporation. Biotechnol (NY) 13:1205–1209 Google Scholar Prausnitz MR (1996) The effects of electric current applied to skin: a review for transdermal drug delivery.Author: Babu M. Medi, Buddhadev Layek, Jagdish Singh
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