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https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/transdermal-insulin-delivery/
Transdermal Insulin Delivery One of the skin’s primary roles is to provide protection against infection and physical damage. This barrier is so effective that it prevents many pharmaceutical compounds from crossing into the bloodstream.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556146/
Jan 15, 2019 · A transdermal delivery strategy transports insulin across the skin barrier represents a minimally invasive and attractive method for insulin delivery in contrast to painful hypodermic injections [24, 25]. It also has several advantages over oral, pulmonary, and nasal administration techniques.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152630/
Transdermal delivery of insulin is attractive as a noninvasive method that offers the convenience of a transdermal patch . However, the skin’s barrier properties prevent absorption of useful amounts of insulin.Author: Samantha Andrews, Jeong Woo Lee, Seong-O Choi, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0169409X18303090
A transdermal delivery strategy that transports insulin across the skin barrier represents a minimally invasive and attractive method for insulin delivery in contrast to painful hypodermic injections [ 24, 25 ]. It also has several advantages over oral, pulmonary, and nasal administration techniques.Author: Yuqi Zhang, Yuqi Zhang, Jicheng Yu, Anna R. Kahkoska, Jinqiang Wang, Jinqiang Wang, John B. Buse, Zh...
https://professional.diabetes.org/abstract/transdermal-delivery-insulin-patients-type-1-diabetes
Transdermal Delivery of Insulin in Patients with Type 1 Diabetes A novel daily transdermal insu A novel daily transdermal insulin patch is being developed to provide basal levels of insulin in patients with type 1 or type 2 diabetes.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/transdermal-delivery
In general, it seems that a transdermal delivery system for insulin is an attractive option. Even though progress in the transdermal delivery of insulin seems promising, because of the poor permeation capacity of insulin and the high susceptibility of the skin to adverse immunological reactions, it is still doubtful whether this delivery route can provide a general approach to the non-invasive delivery of insulin.
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