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https://www.sciencedirect.com/science/article/pii/S0169409X01001843
Oct 01, 2001 · The pharmacodynamics and pharmacokinetic modelling of nanoparticle transcytosis and translocation would encompass many rate-limiting steps as indicated in Table 1 and would certainly be dependent on the surface nature of the particles but more crucially on the particulate size . For biodegradable particles continual erosion would result in a size able to permeate the trabecular meshwork of the mesentery node for systemic …Author: Alexander T Florence, Nasir Hussain
https://www.sciencedirect.com/science/article/abs/pii/S0169409X01001843
Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas ... particulate matter across the gastrointestinal tract is now a well documented phenomenon offering new potential for the delivery of drugs with poor dissolution profiles and labile chemistries via encapsulation in biodegradable nanoparticles. ... adhesion, uptake ...Author: Alexander T Florence, Nasir Hussain
https://www.researchgate.net/publication/11771182_Transcytosis_of_nanoparticle_and_dendrimer_delivery_systems_Evolving_vistas
Transcytosis of nanoparticles is adversely affected by the enteric coating after the initial adsorption by salivary proteins [17]. Nanoparticle uptake by rat gastrointestinal mucosa indicated that ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857052/
Oct 17, 2019 · Transcytosis is a type of transcellular transport across the interior of a cell which extensively studied initially for macromolecules delivery through the blood-brain barrier (BBB) 30, 44-54. Actually, transcytosis-based mechanism has been used to achieve efficient delivery of drugs and genes by nanocarriers to various tissues 55-58.Author: Xiangsheng Liu, Jinhong Jiang, Huan Meng
https://www.thno.org/v09p8018.htm
Transcytosis - An effective targeting strategy that is complementary to “EPR effect” for pancreatic cancer nano drug delivery Xiangsheng Liu 1,2* , Jinhong Jiang 1,2* , Huan Meng 1,2 1.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238330/
Florence AT, Hussain N. Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev. 2001; 50 (Suppl 1):S69–S89. Gelperina S, Kisich K, Iseman MD, Heifets L. The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am J Respir Crit Care Med. 2005; 172 (12):1487–1490.Author: Jonathan Paul Smith
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718451/
Dec 15, 2005 · Although identifying novel anti-TB agents remains a priority, the development of the nanoparticle-based delivery systems for currently used agents may represent a cost-effective and promising alternative. The above data suggest that nanoparticles have a considerable potential for treatment of TB.Author: Svetlana Gelperina, Kevin Kisich, Michael D. Iseman, Leonid Heifets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412909/
Aug 10, 2012 · Receptor-mediated transcytosis: a mechanism for active extravascular transport of nanoparticles in solid tumors. *Corresponding author: Department of Experimental Diagnostic Imaging, Unit 59, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030. Phone: (713) 792-5182.Author: Wei Lu, Chiyi Xiong, Rui Zhang, Lifang Shi, Miao Huang, Guodong Zhang, Shaoli Song, Qian Huang, Gang...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The aims for nanoparticle entrapment of drugs are either enhanced delivery to, or uptake by, target cells and/or a reduction in the toxicity of the free drug to non-target organs. Both situations will result in an increase of therapeutic index, the margin between the doses resulting in a therapeutic efficacy (eg,...Author: Wim H De Jong, Paul Ja Borm
https://www.sciencedirect.com/science/article/pii/B9780128136898000021
Nanoparticle drug delivery systems (NPDDS) achieve superior entry for the particles inside the body, as their size permits conveyance by means of intravenous infusion or different courses. Another important use of the NPDDS is in the production of the antibodies …Author: Deepti Sharma, Navneet Sharma, Mallika Pathak, Paban K. Agrawala, Mitra Basu, Himanshu Ojha
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