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https://dspace.mit.edu/handle/1721.1/81667
Many of the current limitations in vaccine availability and administration are the result of obligate needle-based delivery, which in addition to contributing to reduced speed, ease, and compliance in administration, has been shown to contribute to reduced overall safety due to …Author: Peter C. DeMuth
https://www.sciencedirect.com/science/article/pii/S0378517317308293
Microneedle (MN) patches have great potential as transcutaneous vaccine delivery devices because MNs can effectively deliver vaccine antigen into the skin through the micropores formed in the stratum corneum by low-invasive and painless skin puncturing.Author: Akihiko Ono, Hiroaki Azukizawa, Hiroaki Azukizawa, Sayami Ito, Yuki Nakamura, Hideo Asada, Ying-Shu ...
https://www.nature.com/articles/nm1200_1403
Dec 01, 2000 · Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. In animal studies, this ...Author: Gregory M. Glenn, David N. Taylor, Xiuru Li, Sarah Frankel, Andrew Montemarano, Carl R. Alving
https://www.sciencedirect.com/science/article/pii/S0264410X11009601
3. Novel formulations for transcutaneous vaccine delivery. As it is not easy for large proteins and viral particles to penetrate through the stratum corneum in the natural conditions, the main challenge for transcutaneous immunization is to enhance the across of antigens through the epidermis.Author: Ni Li, Li-Hua Peng, Xi Chen, Shinsaku Nakagawa, Jian-Qing Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322279/
Apr 10, 2012 · A safe and efficient technology is needed, more than ever, for transcutaneous delivery of hydrophilic drugs and vaccines. We show here that a clinical AFL even at a relatively low laser energy (2.5mJ) and covered area (5%) is superior to tape stripping in augmentation of transcutaneous delivery of hydrophilic drugs or a model vaccine OVA.Author: Xinyuan Chen, Dilip Shah, Garuna Kositratna, Dieter Manstein, Richard R. Anderson, Mei X. Wu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252672/
Dec 08, 2011 · Results of this study highlight the nanoscale formulation, flexible liposome, as a promising carrier for the transcutaneous delivery of antigen proteins. Imiquimod was shown to be an effective adjuvant as a transcutaneous immunization enhancer with the potential for …Author: Ni Li, Li-Hua Peng, Xi Chen, Shinsaku Nakagawa, Jian-Qing Gao
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