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https://link.springer.com/article/10.1007/s11095-006-9136-9
Nov 14, 2006 · Thiolated chitosan appears to possess enhanced mucoadhesiveness and cell penetration properties, however, its potential in gene-drug delivery remains unknown. Herein, we report on a highly effective gene delivery system utilizing a 33-kDa thiol-modified chitosan derivative. Thiolated chitosan was prepared by the reaction with thioglycolic acid.Author: Dongwon Lee, Weidong Zhang, Shawna A. Shirley, Xiaoyuan Kong, Gary R. Hellermann, Richard F. Lockey,...
https://www.sciencedirect.com/science/article/pii/S0939641103001474
Thiolated chitosans also display, beside their strong mucoadhesive and permeation enhancing properties, excellent cohesive properties. The reduced thiol functions on the chitosan backbone enable thiolated chitosans not only to form disulfide bonds with mucus glycoproteins, but also to form inter- as well as intra-molecular disulfide bonds.
https://www.sciencedirect.com/science/article/pii/S0141813019348536
In our previous research, cationic polymers of thiolated trimethyl chitosan (TMC-SH) were synthesized to condense plasmid DNA by electrostatic interaction which was the first step for the construction of gene delivery system. The degree of trimethylation is 22% according to 1 H NMR .Author: Qing Liu, Zhu Jin, Wei Huang, Yuanyuan Sheng, Zhongmin Wang, Shengrong Guo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181057/
Thiolated chitosan has high transfection and mucoadhesive properties. We investigated the potential of two recently synthesized polymers: NAC-C (N-acetyl cysteine-chitosan) and NAP-C (N-acetyl penicillamine-chitosan) in anticancer drug delivery targeting epidermal growth factor receptor (EGFR).Author: Fatemeh Talaei, Ebrahim Azizi, Rassoul Dinarvand, Fatemeh Atyabi
https://www.researchgate.net/publication/6694981_Thiolated_ChitosanDNA_Nanocomplexes_Exhibit_Enhanced_and_Sustained_Gene_Delivery
Thiolated chitosan appears to possess enhanced mucoadhesiveness and cell penetration properties, however, its potential in gene-drug delivery remains unknown.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413446/
Jul 18, 2012 · Synthesis of thiolated chitosan and preparation nanoparticles with sodium alginate for ocular drug delivery. ... thiolated chitosan (TCS), ... TCS-SA NPs can delivery more FITC into cornea than CS-SA NPs or FITC solution after the same operation. From the stereomicroscope, we detected that all three kinds of FITC can get into cornea, but the ...Author: Xuan Zhu, Meiqin Su, Shaoheng Tang, Lingsong Wang, Xinfang Liang, Feihong Meng, Ying-Chung Hong, Zhi...
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