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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413446/
Jul 18, 2012 · Nanoparticles have excellent tissue penetration and persistence and for drug delivery, more targeted dosing and longer intervals between doses are beneficial to patients [6,7]. Chitosan (CS), a cationic polysaccharide, has been widely used in ophthalmic therapy . CS is a mucoadhesive polymer that is a promising candidate for ocular therapy because of its biocompatibility, biodegradability, and …Author: Xuan Zhu, Meiqin Su, Shaoheng Tang, Lingsong Wang, Xinfang Liang, Feihong Meng, Ying-Chung Hong, Zhi...
https://pdfs.semanticscholar.org/39b6/574dcaeb849b6bc8ed40ad8d4c0c0c35f76d.pdf
thiolated Chitosan derivatives that have been synthesized so far, as well as their characterization and optimization utilizing various in vitro test systems. The performance of thiolated chitosan in in-vivo studies, providing proof of their applicability in per oral peptide delivery systems, will be …
https://www.sciencedirect.com/science/article/pii/B9780128144275000135
Mucoadhesive Thiolated Chitosan: Next Generation Polymer for Drug Delivery Thiomers are a hydrophilic macromolecule with free thiol groups in their structure. Normally, chitosan doesn't bear any thiol groups in its structural skeleton, but fortunately, the same structure provides opportunities to …Author: Muktika Tekade, Neha Maheshwari, Susanne R. Youngren-Ortiz, Vikas Pandey, Yashu Chourasiya, Vandana ...
https://www.sciencedirect.com/science/article/pii/S0939641103001474
Thiolated chitosan derivatives therefore seem to be promising new excipients for liquid or semisolid formulations, which should stabilize themselves once applied on the site of drug delivery. The in situ gel formation within a pH range from 5 to 6.8 makes the application of thiolated chitosans on vaginal, nasal and ocular mucosa possible.
http://www.nephro-pathology.com/uploads/1/0/0/4/10044970/chitosan_mediated_targeted_drug_delivery.pdf
Chitosan has been widely utilized as drug delivery systems for low molecular drugs, peptides and genes [16, 25, 26]. Despite the recent emergence of biomacromolecular drugs, the majority of therapeutic drugs that are being developed and marketed are primarily low molecular weight drugs.
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Chitosan-based formulations used for ophthalmic drug delivery are hydrogels [43], nanoparticles [44], and coated colloidal systems [45]. Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the eye.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://investigadores.unison.mx/en/publications/synthesis-and-characterization-of-new-thiolated-chitosan-nanopart-2
Gibbs free energy (Δ G) and binding constant (K a) describe the aggregation process of thiolated chitosan/TPP, which is an initial reaction and followed by an endothermic stage. These results are promising for the possible application of these nanoparticles as nanocarriers and delivery systems.
https://www.scientific.net/KEM.342-343.445
Jul 01, 2007 · Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System p.445 Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In VivoAuthor: Ji Shan Quan, Hu Lin Jiang, Yun Jaie Choi, Mi Kyong Yoo, Chong Su Cho
https://pubs.acs.org/doi/10.1021/acsami.9b21528
1 day ago · To improve water solubility and bioavailability, curcumin (Cur) was encapsulated by liposomes (Cur-Lip), which was further coated with thiolated chitosan (CSSH) to form liposomal hydrogels (CSSH/Cur-Lip gel). The hydrogels were thermosensitive with in situ injectable performance, which were fluidic at room temperature and gelled quickly at 37 °C. The cumulative release ratio of the …
https://www.researchgate.net/publication/306245895_Nanosystems_for_intranasal_drug_delivery
Augustijns P., Bernkop-Schn + rch A. Thiolated chitosan . ... Specifically, drug delivery via nanoparticles presents novel therapeutic opportunities for active agents (drugs or genes) that were ...
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