Thiolated Chitosan Drug Delivery

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Synthesis of thiolated chitosan and preparation ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413446/
    Jul 18, 2012 · Nanoparticles have excellent tissue penetration and persistence and for drug delivery, more targeted dosing and longer intervals between doses are beneficial to patients [6,7]. Chitosan (CS), a cationic polysaccharide, has been widely used in ophthalmic therapy . CS is a mucoadhesive polymer that is a promising candidate for ocular therapy because of its biocompatibility, biodegradability, and …Author: Xuan Zhu, Meiqin Su, Shaoheng Tang, Lingsong Wang, Xinfang Liang, Feihong Meng, Ying-Chung Hong, Zhi...

THIOLATED CHITOSAN A GIFT TO MUCOADHESIVE DRUG …

    https://pdfs.semanticscholar.org/39b6/574dcaeb849b6bc8ed40ad8d4c0c0c35f76d.pdf
    thiolated Chitosan derivatives that have been synthesized so far, as well as their characterization and optimization utilizing various in vitro test systems. The performance of thiolated chitosan in in-vivo studies, providing proof of their applicability in per oral peptide delivery systems, will be …

Thiolated-Chitosan: A Novel Mucoadhesive Polymer for ...

    https://www.sciencedirect.com/science/article/pii/B9780128144275000135
    Mucoadhesive Thiolated Chitosan: Next Generation Polymer for Drug Delivery Thiomers are a hydrophilic macromolecule with free thiol groups in their structure. Normally, chitosan doesn't bear any thiol groups in its structural skeleton, but fortunately, the same structure provides opportunities to …Author: Muktika Tekade, Neha Maheshwari, Susanne R. Youngren-Ortiz, Vikas Pandey, Yashu Chourasiya, Vandana ...

Thiolated chitosans - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0939641103001474
    Thiolated chitosan derivatives therefore seem to be promising new excipients for liquid or semisolid formulations, which should stabilize themselves once applied on the site of drug delivery. The in situ gel formation within a pH range from 5 to 6.8 makes the application of thiolated chitosans on vaginal, nasal and ocular mucosa possible.

Chitosan Mediated Targeted Drug Delivery System: A Review

    http://www.nephro-pathology.com/uploads/1/0/0/4/10044970/chitosan_mediated_targeted_drug_delivery.pdf
    Chitosan has been widely utilized as drug delivery systems for low molecular drugs, peptides and genes [16, 25, 26]. Despite the recent emergence of biomacromolecular drugs, the majority of therapeutic drugs that are being developed and marketed are primarily low molecular weight drugs.

Chitosan-based drug delivery systems - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0939641112001038
    Chitosan-based formulations used for ophthalmic drug delivery are hydrogels [43], nanoparticles [44], and coated colloidal systems [45]. Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the eye.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt

Synthesis and characterization of new thiolated chitosan ...

    https://investigadores.unison.mx/en/publications/synthesis-and-characterization-of-new-thiolated-chitosan-nanopart-2
    Gibbs free energy (Δ G) and binding constant (K a) describe the aggregation process of thiolated chitosan/TPP, which is an initial reaction and followed by an endothermic stage. These results are promising for the possible application of these nanoparticles as nanocarriers and delivery systems.

Thiolated Eudragit-Coated Chitosan Microspheres as an Oral ...

    https://www.scientific.net/KEM.342-343.445
    Jul 01, 2007 · Thiolated Eudragit-Coated Chitosan Microspheres as an Oral Drug Delivery System p.445 Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In VivoAuthor: Ji Shan Quan, Hu Lin Jiang, Yun Jaie Choi, Mi Kyong Yoo, Chong Su Cho

Injectable and In Situ-Formable Thiolated Chitosan-Coated ...

    https://pubs.acs.org/doi/10.1021/acsami.9b21528
    1 day ago · To improve water solubility and bioavailability, curcumin (Cur) was encapsulated by liposomes (Cur-Lip), which was further coated with thiolated chitosan (CSSH) to form liposomal hydrogels (CSSH/Cur-Lip gel). The hydrogels were thermosensitive with in situ injectable performance, which were fluidic at room temperature and gelled quickly at 37 °C. The cumulative release ratio of the …

(PDF) Nanosystems for intranasal drug delivery

    https://www.researchgate.net/publication/306245895_Nanosystems_for_intranasal_drug_delivery
    Augustijns P., Bernkop-Schn + rch A. Thiolated chitosan . ... Specifically, drug delivery via nanoparticles presents novel therapeutic opportunities for active agents (drugs or genes) that were ...

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