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https://www.researchgate.net/publication/280718964_Thermogelling_microemulsions_for_topical_delivery_of_griseofulvin
Thermoreversible gels formed in situ by oil-in-water microemulsion were evaluated to improve topical delivery of griseofulvin (GF), a fungistatic antibiotic chosen as a sparingly soluble model drug.
https://www.researchgate.net/publication/280718964_Thermogelling_microemulsions_for_topical_delivery_of_griseofulvin
Thermoreversible gels formed in situ by oil-in-water microemulsion were evaluated to improve topical delivery of griseofulvin (GF), a fungistatic antibiotic chosen as a sparingly soluble model drug.
https://www.sciencedirect.com/science/article/abs/pii/S1773224711500802
Thermogelling microemulsions and control thermogelling solutions showed very low transdermal GF permeation, while the drug accumulation into the skin, after a single 24 h application, was nearly two-fold higher from the microemulsions than from the corresponding polymer solutions.Author: Elena Peira, Marina Gallarate, Rita Spagnolo, Daniela Chirio, Michele Trotta
https://www.sciencedirect.com/science/article/pii/S1773224711500802
Thermogelling microemulsions for topical delivery of griseofulvin E. Peira, * [email protected] M. Gallarate, R. Spagnolo, D. Chirio, M. Trotta, Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, 10125 Torino, Italy Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9 Torino 10125 Italy * Correspondence: Thermoreversible gels formed in situ by oil-in-water ...Author: Elena Peira, Marina Gallarate, Rita Spagnolo, Daniela Chirio, Michele Trotta
http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0507.2006.01221.x/abstract
Apr 25, 2006 · Griseofulvin is a classical oral fungistatic antibiotic, active against Epidermophyton floccosum, Trichophyton and Microsporum species, the causative fungi of tinea corporis. To evaluate the efficacy of topical griseofulvin in the treatment of tinea circinata using …
https://link.springer.com/article/10.1007%2Fs11051-013-1983-9
Sep 15, 2013 · The present study is aimed at evaluation of the dermal delivery potential of griseofulvin-loaded ethosomes. Griseofulvin-loaded ethosomes were prepared using “Cold technique” (Indian Patent Application 208/DEL/2009). The optimized formulation was characterized for vesicular shape and size, drug entrapment efficiency, drug content, pH, stability, and spreadability. Ex vivo skin permeation ...Author: Nidhi Aggarwal, Shishu Goindi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167257/
Jul 02, 2011 · Microemulsions have several advantages such as enhanced drug solubility, good thermodynamic stability, and higher transdermal permeability over conventional formulations (11,12). Many studies reported the use of microemulsions as topical drug delivery vehicles showed their ability to improve transdermal and dermal delivery properties (12–15).Author: Fahima M. Hashem, Dalia S. Shaker, Mohamed Khalid Ghorab, Mohamed Nasr, Aliaa Ismail
https://www.ncbi.nlm.nih.gov/pubmed/25466399
However, low viscosity of microemulsion restrains its applicability in pharmaceutical industry. To overcome the above drawback, the low viscous microemulsions were added to viscous gel bases to potentiate its applications as topical drug delivery systems so that various drug related toxic effects and erratic drug absorption can be avoided.Author: Harini C. Vadlamudi, Hyndavi Narendran, Tejeswari Nagaswaram, Gowri Yaga, Jyotsna Thanniru, Prasanna...
http://michniaklab.org/our-science/topical-transdermal-buccal-drug-delivery/microemulsions-for-transdermal-and-topical-drug-delivery/
Microemulsion internal structural domains are in the micro/nano-scale, typically in the range of 10 – 200 nm. For transdermal and topical drug delivery applications, microemulsions have demonstrated effectiveness in enhancing drug skin permeation and/or skin drug deposition.
https://www.hindawi.com/journals/isrn/2011/780150/
Insulin-loaded microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant. The pseudoternary phase diagrams were constructed to determine the composition of microemulsions. The insulin permeation flux of microemulsions containing oleic acid as oil phase through excised ...Author: Jadupati Malakar, Suma Oomen Sen, Amit Kumar Nayak, Kalyan Kumar Sen
https://link.springer.com/article/10.1208/s12249-016-0643-7
Oct 18, 2016 · In this study, non-aqueous microemulsions were developed because of the challenges associated with finding pharmaceutically acceptable solvents for topical delivery of drugs sparingly soluble in water. The formulation irritation potential and ability to modulate the penetration of lipophilic compounds (progesterone, α-tocopherol, and lycopene) of interest for topical treatment/prevention of ...
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