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https://www.researchgate.net/publication/333576305_Therapeutic_Intranasal_Delivery_for_Alzheimer's_Disease
In book: Therapeutic Intranasal Delivery for Stroke and Neurological Disorders, pp.117-133. ... Here, we compare the efficacy of the two delivery routes of hNGF-61, a recombinant traceable form of ...
https://www.researchgate.net/publication/333576305_Therapeutic_Intranasal_Delivery_for_Alzheimer's_Disease
In book: Therapeutic Intranasal Delivery for Stroke and Neurological Disorders, pp.117-133. ... Here, we compare the efficacy of the two delivery routes of hNGF-61, a recombinant traceable form of ...
https://www.mdedge.com/neurology/article/106892/alzheimers-cognition/intranasal-drug-delivery-bypasses-blood-brain-barrier
Intranasal Drug Delivery Bypasses the Blood–Brain Barrier ... Danielyan L, Schäfer R, von Ameln-Mayerhofer A, et al. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson’s disease. ... Intranasal delivery of therapeutics involves spraying therapeutics into the upper part of the nasal cavity to ...
https://journals.sagepub.com/doi/pdf/10.3727/096368914X684970
system is critical for maintaining therapeutic efficacy and safety in the respective disease models. Our previous data demonstrated therapeutically efficacious and targeted delivery of mesenchymal stem cells (MSCs) to the brain in the rat 6-hydroxydopamine model of Parkinson’s disease (PD). The present study examined delivery
https://www.researchgate.net/publication/333570161_Intranasal_Delivering_Method_in_the_Treatment_of_Ischemic_Stroke
The therapeutic efficacy of intranasal iNOS siRNA delivery was investigated in the postischemic rat brain after encapsulating on in gelatin nanoparticles (GNPs; diameter 188.0±60.9 nm) cross ...
http://jpet.aspetjournals.org/content/370/3/593
The intranasal delivery of quetiapine (an antipsychotic drug) resulted in a C max that was estimated at 0.035% of the dose when dosed as a solution and a C max that was estimated at 0.09% when dosed as chitosan–tripolyphosphate nanoparticles (Shah et al., 2016). From a commercial perspective, solution-based formulations are less appealing as ...
https://www.sciencedirect.com/science/article/pii/S0168365918302682
Hence, various novel strategies have been developed or under investigation to reduce the drugs side effect and enhance the therapeutic efficacy. Intranasal route overcomes the limitation of poor drug absorption by avoiding the BBB and deliver the drug directly to the brain through olfactory route [, , ]. Discussed below are the different ...
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0273
Nov 27, 2019 · Intranasal delivery of therapeutic agents may represent a less invasive strategy for treating critically ill neonates. Relatively few studies have investigated the efficacy of intranasal administration of therapeutic agents for lung disease, and to our knowledge none of the current literature has investigated the use of intranasally delivered ...
https://stemedix.com/intranasal-delivery-of-stem-cells
Mar 21, 2016 · Though research has shown that stem cells are therapeutic candidates for neurodegenerative diseases like Parkinson’s disease, scientists have been working on overcoming the challenges associated with effectively delivering these cells to the brain. A recent study, published in the journal Rejuvenation Research, demonstrated that intranasal delivery of stem cells provided both …
https://pubs.acs.org/doi/10.1021/acsnano.9b01892
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits, while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that when given intranasally, exosomes derived from mesenchymal stem cells (MSC-Exo) could pass the blood brain barrier and migrate to the injured spinal cord area.
http://med.umkc.edu/docs/em/IN_Med_dosing_chart.pdf
Intranasal medications and doses based on published literature Clinical Scenario Intranasal Medication and dose Important reminders Pain control Fentanyl 2.0 ug/kg Ketamine 0.5 to 1 mg/kg •Always monitor for respiratory depression • Only use a device that can very accurately deliver an exact dose of medication.
https://academic.oup.com/neuro-oncology/article/10/2/112/1076068
Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain and could provide an alternative to intravenous injection and convection-enhanced delivery. We treated rats bearing intracerebral human tumor xenografts intranasally with GRN163, an oligonucleotide N3'→P5'thio-phosphoramidate telomerase ...
https://www.ott.nih.gov/technology/e-258-2013-0
This Intranasal Dry Powder Inhaler (DPI), developed with Creare, Inc., allows low-cost delivery of powder vaccines. Nasal delivery has numerous advantages compared to traditional injected vaccines, including: 1) safe, needle-less administration by minimally-trained staff or patient; 2) better protection due to mucosal and cross-protection; and 3) decreased biohazard waste.
https://www.nature.com/articles/s41598-019-55294-5
Dec 18, 2019 · Focused ultrasound-enhanced intranasal (IN + FUS) delivery is a noninvasive approach that utilizes the olfactory pathway to administer pharmacological agents directly to the brain, allowing for a ...
https://academic.oup.com/ajhp/article/72/18/1544/5111731
Sep 15, 2015 · Intranasal delivery options ... Previous studies have noted that haloperidol concentrations of 5–15 ng/mL are associated with therapeutic efficacy, 76 and a clinically relevant maximum concentration (C max) of 9.8 ng/mL and a bioavailability of 63.8% were noted by Miller and colleagues after intranasal administration.
https://www.dovepress.com/intranasal-delivery-of-bone-marrow-stromal-cells-preconditioned-with-f-peer-reviewed-fulltext-article-NDT
Intranasal Delivery of Bone Marrow Stromal Cells Preconditioned with Fasudil to Treat a Mouse Model of Parkinson’s Disease ... Danielyan L, Schäfer R, von Ameln-mayerhofer A, et al. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease.
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