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https://www.ncbi.nlm.nih.gov/pubmed/9719859
Theoretical models for drug delivery to solid tumors. el-Kareh AW(1), Secomb TW. Author information: (1)Department of Physiology, University of Arizona, Tucson 85724-5051, USA. The effectiveness of anti-cancer drug therapies is often limited by the difficulty of achieving drug delivery throughout solid tumors.Author: A. W. El-Kareh, Timothy Secomb
https://core.ac.uk/download/pdf/143820640.pdf
prepared by Jackson Burton, titled Theoretical Models for Drug Delivery to Solid Tumors and recommend that it be accepted as fulfilling the dissertation requirement for the Degree of Doctor of Philosophy. _____ Date: November 29, 2016 Timothy W. Secomb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
Jul 22, 2014 · In order to arrive at the appropriate solutions we must first seek to identify and understand the problems. The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. 2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast ...Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
https://faculty.eng.ufl.edu/soft-tissue-mechanics-drug-delivery/research/
Uneven drug coverage is a major problem encountered in chemotherapy since the clinical goal is to eliminate 100% of tumor cells. Our lab is developing theoretical mechanics models of solid tumors where leaky vessels and cell proliferation contribute to abnormal flow and tissue deformation patterns that adversely affect drug delivery.
https://www.sciencedirect.com/science/article/pii/S0168365919303244
Mathematical and numerical simulations are an integral part of research in DDSs. These models help predict drug delivery efficiency and therapeutic efficacy of the nanomedicines . Various modeling techniques have been proposed to simulate DDSs of interest at …Author: Milad Shamsi, Amir Mohammadi, Mohammad K.D. Manshadi, Amir Sanati-Nezhad
https://www.sciencedirect.com/science/article/pii/S0169409X18301790
Computational modelling of drug delivery to solid tumour: ... computational models of drug delivery need to provide a detailed description of the series of drug transport steps. ... J. Krishnan, J. Stebbing, X.Y. XuUse of mathematical models to understand anticancer drug delivery and its effect on solid tumors.Author: Wenbo Zhan, Moath Alamer, Xiao Yun Xu
https://link.springer.com/article/10.1114/1.1540103
Solid tumors consist of a porous interstitium and a neoplastic vasculature composed of a network of capillaries with highly permeable walls. Blood flows across the vasculature from the arterial entrance point to the venous exit point, and enters the tumor by convective and diffusive extravasation through the permeable capillary walls. In this paper, an integrated theoretical model of the flow ...Author: C. Pozrikidis, D. A. Farrow
https://www.researchgate.net/publication/231583060_Drug_Delivery_and_Transport_to_Solid_Tumors
Part IV summarizes the experimental approaches used to enhance drug delivery and transport in solid tumors. Drug delivery to solid tumors consists of multiple processes, including transport via ...
https://www.dovepress.com/drug-delivery-to-solid-tumors-the--predictive-value-of-the-multicellul-peer-reviewed-fulltext-article-IJN
Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening Marie Millard,1,2 Ilya Yakavets,1–3 Vladimir Zorin,3,4 Aigul Kulmukhamedova,1,2,5 Sophie Marchal,1,2 Lina Bezdetnaya1,2 1Centre de Recherche en Automatique de Nancy, Centre National de la Recherche Scientifique UMR 7039, Université de Lorraine, …Author: Marie Millard, Ilya Yakavets, Vladimir Zorin, Aigul Kulmukhamedova, Sophie Marchal, Lina Bezdetnaya
https://link.springer.com/article/10.1208/s12248-019-0390-2
Dec 11, 2019 · Antibody-drug conjugates (ADCs) are cancer drugs composed of a humanized antibody linked to a cytotoxic payload, allowing preferential release of payload in cancer cells expressing the antibody-targeted antigen. Here, a systems pharmacology model is used to simulate ADC transport from blood to tumor tissue and ADC uptake by tumor cells. The model includes effects of spatial gradients …Author: Jackson K. Burton, Dean Bottino, Timothy W. Secomb
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