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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally 4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach.
http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
The oral delivery of protein and peptide drugs A variety of strategies can be used to overcome the barriers to protein/ peptide drug delivery by the oral route. Dr Richard Soltero and Dr Nnochiri Ekwuribe, Nobex Corporation T he use of polypeptides and proteins for
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
Despite the large number of protein therapeutics being discovered each year, oral delivery continues to be a barrier. As a whole, protein and peptide drugs have low bioavailability when administered orally due to problematic barriers including gastrointestinal proteases, the epithelial barrier and efflux pumps.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
oral administration of protein and peptide drugs are the same, that is, to avoid enzymatic degradation in the digestive system, and to improve the drug oral bioavailability (23). Mucus Barrier Mucus is composed of mucin, enzymes, electrolytes, and water, which acts as a lubricant and protects the intestine (24,25).Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.Author: Josias H. Hamman, Gill M. Enslin, Awie F. Kotzé
https://www.sciencedirect.com/science/article/pii/S1319016414000590
The two important approaches for formulation of protein and peptides by oral route include: use of absorption enhancers and enzymatic inhibitor. Being charged, large in size and hydrophilic, proteins and peptides are notoriously poor permeators (and thus exhibit poor oral bioavailability per se).Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.sciencedirect.com/science/article/pii/S1359644606003084
It has been demonstrated that receptor-mediated endocytosis of VB 12 could be used for oral delivery of peptides and proteins. Transferrin is also useful as a carrier for oral delivery of protein drugs such as insulin and granulocyte colony-stimulating factor (G-CSF).Author: Mariko Morishita, Nicholas A. Peppas
https://www.researchgate.net/publication/40834786_Protein_and_Peptide_Drug_Delivery_Oral_Approaches
Oral Delivery of Proteins and P eptides Till recent, injections r emained the most common means for administering therapeutic proteins and peptides because of their poor oral bioavailability....
https://advances.sciencemag.org/content/6/14/eaba0145.full
10 days ago · The key factor that limits development of oral delivery of protein and peptide drugs is the existence of multiple physical and biological barriers in the gastrointestinal (GI) tract, including the...
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