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http://www.iptonline.com/articles/public/IPTNINE106NoPrint.pdf
DRUG FORMULATION & DELIVERY The oral delivery of protein and peptide drugs A variety of strategies can be used to overcome the barriers to protein/ peptide drug delivery by the oral route. Dr Richard Soltero and Dr Nnochiri Ekwuribe, Nobex Corporation T he use of polypeptides and proteins for systemic treatment of certain diseases isFile Size: 228KB
https://onlinelibrary.wiley.com/doi/10.1002/0471475734.ch10
Oral Protein and Peptide Drug Delivery. ... Rick Soltero. Pharma Directions, Inc., USA. Search for more papers by this author. Book Editor(s): Binghe Wang. Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Search for more papers by this author.Author: Rick Soltero
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
Designing oral peptide and protein delivery systems has been a persistent challenge to pharmaceutical scientists because of their several unfavorable physicochemical properties including large molecular size, susceptibility to enzymatic degradation, short plasma half-life, ion permeability, immunogenicity, and the tendency to undergo aggregation, adsorption, and denaturation 12,13. Consequently, the …
https://www.nature.com/articles/s41578-019-0156-6
Dec 24, 2019 · Although oral delivery works well for small-molecule drugs, oral delivery of macromolecules (particularly proteins and peptides) has been limited by acidic conditions in the stomach and low ...Author: Tyler D. Brown, Tyler D. Brown, Kathryn A. Whitehead, Samir Mitragotri, Samir Mitragotri
https://blogs.sciencemag.org/pipeline/archives/2019/12/18/proteins-as-oral-drugs-possible-but-not-probable
I have been writing this blog for some time (!) That occurs to me on seeing this article in Nature Reviews Drug Discovery on oral dosing of peptide drugs – I say that because of this 2002 post on the very same subject, at the time directed towards the then-still-somewhat-hot topic of Judah Folkman’s endostatin angiogenesis inhibitor (which was itself a peptide).
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
oral administration of protein and peptide drugs are the same, that is, to avoid enzymatic degradation in the digestive system, and to improve the drug oral bioavailability (23). Mucus Barrier Mucus is composed of mucin, enzymes, electrolytes, and water, which acts as a lubricant and protects the intestine (24,25).Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.Author: Josias H. Hamman, Gill M. Enslin, Awie F. Kotzé
https://www.sciencedirect.com/science/article/pii/S1359644606003084
Administering drugs orally is by far the most widely used route of administration, although it is generally not feasible for peptide and protein drugs. The main reasons for the low oral bioavailability of biologicals are presystemic enzymatic degradation and poor penetration of the intestinal membrane 4…Author: Mariko Morishita, Nicholas A. Peppas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407643/
Among non-invasive routes, oral delivery is the primary route for administration of small molecules however; it is not preferable for proteins and peptides. Oral delivery of proteins and peptides is highly challenging due to presence of proteolytic enzymes in gastrointestinal tract (GIT) and their intrinsic physicochemical and biological properties like poor stability in lower pH of gastric fluid, large molecular size and poor permeation across gastrointestinal membrane . Nasal and pulmonary ...Author: Ashaben Patel, Mitesh Patel, Xiaoyan Yang, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/S1319016414000590
Being invasive, parenteral route is inconvenient for the administration of protein and peptides, several research endeavors have been undertaken to formulate a better delivery system for proteins and peptides with major emphasis on non-invasive routes such as oral, transdermal, vaginal, rectal, pulmonary and intrauterine.Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
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