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https://www.sciencedirect.com/science/article/pii/S0169409X09002191
Sep 30, 2009 · The data indicate that once elongated scaffolds extravasate into the tumor tissue from the blood vessels, they become physically trapped and do not re-enter the blood stream. Thus, it is evident that shape of the nanoscale scaffold plays a vital role in the design of scaffolds for targeted drug delivery.Author: David Vance, Jacob Martin, Sanket Patke, Ravi S. Kane
https://www.researchgate.net/publication/26664772_The_design_of_polyvalent_scaffolds_for_targeted_delivery
The concept of polyvalency can also be used to design synthetic scaffolds for applications ranging from the design of inhibitors for toxins and pathogens to delivery and imaging.
https://www.deepdyve.com/lp/elsevier/the-design-of-polyvalent-scaffolds-for-targeted-delivery-zUS08sNmQl
Sep 30, 2009 · The design of polyvalent scaffolds for targeted delivery The concept of polyvalency can also be used to design synthetic scaffolds for applications ranging from the design of inhibitors for toxins and pathogens to delivery and imaging.
https://www.researchgate.net/publication/5302161_The_Design_of_Polyvalent_Therapeutics
Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136935/
We used a biocompatible polyamino acid polymer as a scaffold for grafting multiple copies of an oligonucleotide aptamer (OA). Specifically, the carboxylates on the side chains of polyglutamic acid (PGA) were modified with a thiol-reactive linker, N -aminoethyl maleimide (AEM), and thiol-functionalized OAs were attached to the maleimide moieties.Author: Jacob T Martin, Marc Douaisi, Ammar Arsiwala, Manish Arha, Ravi S Kane
https://www.future-science.com/doi/abs/10.4155/tde-2017-0014
May 22, 2017 · Liposomes benefit from the increased physical and mechanical strength, favorable rheological properties and natural environment conducive to improved tissue formation that scaffolds provide, while enabling biocompatible delivery of hydrophilic and lipophilic compounds that can be further functionalized to achieve targeted delivery.Author: Claudia Zylberberg, Sandro Matosevic
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/61/issue/11
Sep 30, 2009 · Read the latest articles of Advanced Drug Delivery Reviews at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
http://www.ijpsnonline.com/Issues/113.pdf
Vikas V. Gaikwad et al. : Scaffolds for Drug Delivery in Tissue Engineering 117 Collagen and gelatin Collagen is a major structural component of connective tissues and organs. Surface immobilization of collagen is one of the most established methods for modulating the adhesive properties to the scaffolds.
https://pubs.acs.org/doi/abs/10.1021/bm060098v
We report the controlled radical copolymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) with a monomer containing an active ester, N-methacryloyloxysuccinimide (NMS), by reversible addition fragmentation chain transfer (RAFT). The large difference in the reactivity ratios of HPMA and NMS resulted in significant variations in copolymer composition with increasing conversion during batch ...Author: Mallinamadugu J. Yanjarappa, Kunal V. Gujraty, Amit Joshi, and Arundhati Saraph, Ravi S. Kane
https://www.nature.com/articles/nmat2992
Apr 17, 2011 · Targeted delivery of drugs encapsulated within nanocarriers 1,2 can overcome problems exhibited by conventional ‘free’ drugs, including poor solubility, limited stability, rapid and, in particular, lack of selectivity, which results in nonspecific toxicity to normal cells 3 and prevents the dose escalation necessary to eradicate malignant cells...Author: Carlee E. Ashley, Carlee E. Ashley, Eric C. Carnes, Genevieve K. Phillips, David P Padilla, Paul N. ...
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