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https://www.sciencedirect.com/science/article/pii/S1359644600003263
The cellular delivery of antisense oligonucleotides and ribozymes. ... The design and development of antisense oligonucleotides and ribozymes for the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic acids ...Author: Marcus D Hughes, Majad Hussain, Qamar Nawaz, Pakeeza Sayyed, Saghir Akhtar
https://www.deepdyve.com/lp/elsevier/the-cellular-delivery-of-antisense-oligonucleotides-and-ribozymes-BQ0xsWVqWO
Mar 15, 2001 · The design and development of antisense oligonucleotides and ribozymes for the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic acids that are relatively stable in the biological milieu. However, advances in cellular targeting and intracellular …
https://www.academia.edu/29620208/The_cellular_delivery_of_antisense_oligonucleotides_and_ribozymes
The cellular delivery of antisense oligonucleotides and ribozymes
https://www.sciencedirect.com/science/article/pii/S0169409X00000806
Oct 31, 2000 · Antisense oligonucleotides, ribozymes and DNAzymes have emerged as novel, highly selective inhibitors or modulators of gene expression. Indeed, their use in the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years.Author: Saghir Akhtar, Marcus D. Hughes, Marcus D. Hughes, Alim Khan, Alim Khan, Mike Bibby, Majad Hussain, ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(01)90481-2
Nov 01, 2001 · The efficacies of antisense oligonucleotides and ribozymes are greatly dependent on the accessibility of their mRNA targets. Target site accessibility is affected by both RNA structure and the proteins associated along the length of the RNA. To mimic the native state of mRNA for site identification, we have previously used endogenous mRNAs in cellular extracts as targets for defined sequence ...Author: Michaela Scherr, Michaela Scherr, Jeanne LeBon, Daniela Castanotto, Heather E. Cunliffe, Paul S. Mel...
https://www.researchgate.net/publication/267682608_Antisense_and_Ribozyme_Therapy
delivery of antisense ODNs and ribozymes. ... These studies also suggest the utility of ribozymes in the analysis of cellular gene expression. ... There is enormous potential in antisense and ...
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