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https://www.ncbi.nlm.nih.gov/pubmed/27020469
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a …Author: William M. Pardridge
https://www.drugtargetreview.com/news/36234/deliver-blood-brain/
Oct 19, 2018 · Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue… Research on the delivery of therapeutics to the brain could have implications for the treatment of a wide range of diseases,...
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and …
https://www.researchgate.net/publication/299492074_CSF_blood-brain_barrier_and_brain_drug_delivery
(BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a measure of BBB...
The Blood-Brain Barrier Delivery Summit (B3DD) is the industry’s first conference dedicated to addressing the translational challenges of effective and safe delivery of CNS drug candidates.
https://www.hindawi.com/journals/bmri/2014/869269/
Therefore, for successful delivery of drugs, blood brain barrier disruption or opening is done by ultrasound and largely used as intra-arterial infusion therapy. It allows both the chemotherapeutic agents and antibodies to enter through blood brain barrier . Hence, BBB dysfunction could be of great therapeutic value in conditions in which neuronal damage is secondary or exacerbated by BBB damage.Author: Ravi Kant Upadhyay
https://www.sciencedirect.com/science/article/pii/S0168365916303236
Blood–brain barrier (BBB) transport mechanisms for brain delivery of nanoparticles (NPs). The BBB is highly selective and has specific transport mechanisms allowing a close control of molecules/cells that enter the brain parenchyma.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes.Author: Leah R Hanson, William H Frey, William H Frey
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