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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255357/
This update review is on mucoadhesive polymers used in nasal dosage forms. The nasal mucosa provides a potentially good route for systemic drug delivery. One of the most important features of the nasal route is that it avoids first-pass hepatic metabolism, thereby reducing metabolism. The ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/
Mucoadhesive drug delivery systems have applications from different angles, including development of novel mucoadhesives, design of the device, mechanisms of mucoadhesion and permeation enhancement. With the influx of a large number of new drug molecules due to drug discovery, mucoadhesive drug delivery will play an even more important role in ...
https://www.tandfonline.com/doi/abs/10.3109/03639040903170750
Background: Over the last decades, the application of mucoadhesive polymers in nasal drug delivery systems has gained interest among pharmaceutical scientists as a means of promoting dosage form residence time in the nasal cavity as well as improving intimacy of contact with absorptive membranes of the biological system.In addition, the enhanced paracellular absorption following the swelling ...Author: Lingmin Jiang, Lei Gao, Xiaoqing Wang, Liang Tang, Jianli Ma
https://www.sciencedirect.com/science/article/pii/S0169409X05001432
Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that low absorption of drugs can be countered by using absorption enhancers or increasing the drug residence time in the nasal cavity, and that some mucoadhesive polymers can serve both functions.Author: Michael I. Ugwoke, Remigius U. Agu, Norbert Verbeke, Renaat Kinget
https://www.sciencedirect.com/science/article/pii/B9780123849359100033
The latter technique is the most extensively investigated, including the search for next generation mucoadhesive polymers and novel nasal delivery products . The mechanisms of mucoadhesion fundamentally involve chemical interaction and interpenetration of the polymer (in this case, the polymer added to the drug formulation) with the mucin chains.Author: Garnpimol C. Ritthidej
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5b00264
The feasibility of various cellulose polymer derivatives, including methylcellulose (MC), hydroxypropyl methylcellulose (HPMC), sodium-carboxymethylcellulose (sodium-CMC), and cationic-hydroxyethylcellulose (cationic-HEC), for use as an excipient to enhance drug delivery in nasal spray formulations was investigated. Three main parameters for evaluating the polymers in nasal drug …Author: Kellisa Hansen, Gwangseong Kim, Kashappa Goud H. Desai, Hiren Patel, Karl F. Olsen, Jaime Curtis-Fis...
https://www.researchgate.net/publication/285201248_Mucoadhesive_polymers_Means_of_improving_drug_delivery
Over the last few decades, the application of mucoadhesive polymers in nasal drug delivery systems has gained interest among pharmaceutical scientists as a means of promoting dosage form residence ...
https://www.researchgate.net/publication/221750128_A_review_on_mucoadhesive_polymer_used_in_nasal_drug_delivery_system/fulltext/57ebf87408ae92eb4d263f3b/221750128_A_review_on_mucoadhesive_polymer_used_in_nasal_drug_delivery_system.pdf
A review on mucoadhesive polymer used in nasal drug delivery system Abstract This update review is on mucoadhesive polymers used in nasal dosage forms. The nasal mucosa provides a potentially good ...
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/novel-mucoadhesive-polymers-for-nasal-drug-delivery
The application of lectins, thiomers, alginate poly-ethylene glycol acrylate and poloxamers were discussed in this chapter. These polymers are not the only polymers used for nasal delivery. However, they are among the least reviewed polymers for systemic drug delivery via the nasal route.Author: Utkarshini Anand, Tiam Feridooni, Remigius U. Agu
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