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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482480/
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers. 2008b; 90:604–10. Torchilin VP, Rammohan R, Weissig V, Levchenko TS. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors.Author: Erez Koren, Anjali Apte, Rupa R. Sawant, Jacob Grunwald, Vladimir P. Torchilin
https://www.nature.com/articles/s41598-019-42456-8
Apr 18, 2019 · HA-TAT peptide has previously been used to deliver peptides and proteins into the cytosol ... including HepG2 which was used to establish this peptide as a CPP for the delivery of organic ...Author: Sanjay G. Patel, Edward J. Sayers, Lin He, Rohan Narayan, Thomas L. Williams, Emily M. Mills, Rudolf...
https://www.sciencedirect.com/science/article/pii/S0076687903720199
The average number of Tat peptide molecules attached per liposome had earlier been estimated from radioactivity data 8 (assuming that practically all Tat peptides are labeled with indium-111 via the attached DTPA residues, and ∼3 × 10 5 molecules of a lipid form a liposome with an average diameter of 200 nm, 9 approximately 500 Tat peptide ...Author: Tatiana S Levchenko, Ram Rammohan, Natalia Volodina, Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013572/
Sep 07, 2016 · A branched TAT cell-penetrating peptide as a novel delivery carrier for the efficient gene transfection. ... Thus, here we designed a branched CPP using disulfide bridges based on the linear TAT peptide, to enhance the gene delivery efficiency in a better way. Results.Author: Chanuk Jeong, Jisang Yoo, DaeYong Lee, Yeu-Chun Kim
https://www.sciencedirect.com/science/article/pii/S0169409X04002741
Peptides are emerging as attractive drug delivery tools. The HIV Tat-derived peptide is a small basic peptide that has been successfully shown to deliver a large variety of cargoes, from small particles to proteins, peptides and nucleic acids.Author: Hilary Brooks, Bernard Lebleu, Eric Vivès
https://www.pnas.org/content/98/15/8786
Jul 17, 2001 · To achieve an efficient intracellular drug and DNA delivery, attempts were made to target microparticulate drug carriers into cytoplasm bypassing the endocytotic pathway. TAT peptides derived from the HIV-1 TAT protein facilitate intracellular delivery of proteins and small colloidal particles. We demonstrated that relatively large drug carriers, such as 200-nm liposomes, can also be delivered ...Author: Vladimir P. Torchilin, Ram Rammohan, Volkmar Weissig, Tatyana S. Levchenko
https://pubs.acs.org/doi/abs/10.1021/ja211035w
Most present nanodrug delivery systems have been developed to target cancer cells but rarely nuclei. However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time. Monodispersed ...Author: Limin Pan, Qianjun He, Jianan Liu, Yu Chen, Ming Ma, Linlin Zhang, Jianlin Shi
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-016-0076-0
Sep 07, 2016 · Thus, here we designed a branched CPP using disulfide bridges based on the linear TAT peptide, to enhance the gene delivery efficiency in a better way. The branched TAT (BTAT) was synthesized by the DMSO oxidation method and showed high-molecular-weight about 294 kDa.Author: Chanuk Jeong, Jisang Yoo, DaeYong Lee, Yeu-Chun Kim
https://www.dovepress.com/topical-ocular-delivery-to-laser-induced-choroidal-neovascularization--peer-reviewed-fulltext-article-IJN
Feb 17, 2017 · Topical ocular delivery to laser-induced choroidal neovascularization by dual internalizing RGD and TAT peptide-modified nanoparticles Yongchao Chu,1,* Ning Chen,2,* Huajun Yu,2,* Hongjie Mu,1 Bin He,1 Hongchen Hua,1 Aiping Wang,1 Kaoxiang Sun1 1School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, …Author: Yongchao Chu, Ning Chen, Huajun Yu, Hongjie Mu, Bin He, Hongchen Hua, Aiping Wang, Kaoxiang Sun
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