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https://www.sciencedirect.com/science/article/pii/S1471489206001251
Oligonucleotide delivery. Efficient delivery of ONs such as small interfering RNAs (siRNAs), decoy-ONs and plasmids, and their analogues such as peptide nucleic acids (PNAs), locked nucleic acids (LNAs) and phosphorodiamidate morpholino oligomers (PMOs), are desired for controlling gene expression or for silencing the activity of certain proteins.Author: Maarja Mäe, Ülo Langel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130259/
Splice-correction assay. HeLa pLuc705 cells (5 × 10 4) were seeded 24 h prior to experiments into 24-well plates.PS-2′-OMe SCOs were mixed with PF14 at different molar ratios (MRs) in MQ-water in 10% of the final treatment volume (i.e. 50 μl).Complexes were formed for 1 h at room temperature and meanwhile the cell medium was replaced in the wells with fresh serum-free or serum-containing ...Author: Kariem Ezzat, Samir El Andaloussi, Eman M. Zaghloul, Taavi Lehto, Staffan Lindberg, Pedro M. D. More...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475625/
Jun 16, 2008 · The potential use of antisense and siRNA oligonucleotides as therapeutic agents has elicited a great deal of interest. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
https://www.sciencedirect.com/science/article/pii/S0169409X04002741
Because of the highly cationic nature of the Tat peptide, the improvement of binding affinity and kinetics of a Tat-oligonucleotide chimera is also expected and should be considered an important issue for Tat-mediated oligonucleotide delivery.Author: Hilary Brooks, Bernard Lebleu, Eric Vivès
https://link.springer.com/10.1007/s11095-005-8330-5
Oct 01, 2005 · Dendrimer–oligonucleotide complexes were moderately effective for delivery of antisense and only poorly effective for delivery of siRNA. Conjugation of the dendrimer with the Tat cell penetrating peptide failed to further enhance the effectiveness of the dendrimer.Author: Hyunmin Kang, Robert DeLong, Michael H. Fisher, Rudolph L. Juliano
https://www.researchgate.net/publication/6924705_Cell-penetrating_peptides_as_vectors_for_peptide_protein_and_oligonucleotide_delivery
Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery Article · Literature Review in Current Opinion in Pharmacology 6(5):509-14 · November 2006 with 28 Reads
https://academic.oup.com/nar/article/36/12/4158/1132931
Jun 16, 2008 · Ultimately, the oligonucleotide must exit from the endosome to reach its site of action in the cytosol or nucleus. Thus, in order to understand key issues in the intracellular delivery of oligonucleotides it is important to consider the multiple routes of endocytosis and the complex trafficking pathways that exist in cells.Author: Rudy Juliano, Md. Rowshon Alam, Vidula Dixit, Hyumin Kang
http://yoksis.bilkent.edu.tr/pdf/files/11527.pdf
second major obstacle in oligonucleotide delivery is the poor cell penetration capability of oligonucleotide-based drugs, which stems from their heavily negative charges.6 The negative charges of the oligonucleotide and the cell membrane act to repel the drug from the membrane, which complicates the mechanism of cellular internalization.
https://www.mdpi.com/2227-9059/6/2/51/htm
The greatest success is likely to come for targeting organs that are most refractory to systemic naked oligonucleotide delivery such as the central nervous system, heart, and skeletal muscle where the need for effective delivery is paramount to realize the power of specific gene and disease mutation targeting that oligonucleotides offer.Author: Graham McClorey, Subhashis Banerjee
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