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https://academic.oup.com/cardiovascres/article/73/3/453/367211
Feb 01, 2007 · Adenoviral vectors are the most frequently used system in experimental and clinical gene transfer studies targeting the heart since they enable highly efficient cardiac gene delivery and can be produced in sufficient quantities.Author: Oliver J. Müller, Hugo A. Katus, Raffi Bekeredjian
https://www.ncbi.nlm.nih.gov/pubmed/17097076
Feb 01, 2007 · Targeting the heart with gene therapy-optimized gene delivery methods. Müller OJ(1), Katus HA, Bekeredjian R. Author information: (1)Internal Medicine III, University of Heidelberg, Germany. [email protected]: Oliver J. Müller, Hugo A. Katus, Raffi Bekeredjian
https://www.researchgate.net/publication/6700499_Targeting_the_heart_with_gene_therapy-optimized_gene_delivery_methods
One of the major hurdles for effective cardiovascular gene therapy is the delivery of the viral vectors to the heart.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865214/
Vector-mediated cardiac gene therapy holds tremendous promise as a translatable platform technology for treating many cardiovascular diseases. The ideal technique is one that is efficient and practical, allowing for global cardiac gene expression, while minimizing collateral expression in …Author: Michael G. Katz, JaBaris D. Swain, Jennifer D. White, David Low, Hansell Stedman, Charles R. Bridges
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.9057
Different vector systems for cardiac gene therapy have been developed in recent years. While non-viral vectors, such as plasmid DNA, allow remarkable organ specificity, they are often limited by low transfection efficiency and transient gene expression.
https://www.nature.com/articles/s41434-019-0119-y
Jan 03, 2020 · In conclusion, this work provides a strong rationale for integrating viral vector and optimized gene-editing technologies to bring about enhanced RGN delivery and performance.Author: Ignazio Maggio, Hidde A. Zittersteijn, Qian Wang, Jin Liu, Josephine M. Janssen, Ivan Toral Ojeda, S...
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