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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
Thus, the advantages of using nanoparticles for drug delivery are a result of two main basic properties: small size and use of biodegradable materials. Nanoparticles, because of their small size, can extravasate through the endothelium in inflammatory sites, epithelium (e.g., intestinal tract and liver), tumors, or penetrate microcapillaries.Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
The kind of hazards that are introduced by using nanoparticles for drug delivery are beyond that posed by conventional hazards imposed by chemicals in classical delivery matrices. For nanoparticles the knowledge on particle toxicity as obtained in inhalation toxicity shows the way how to investigate the potential hazards of nanoparticles.Author: Wim H De Jong, Paul Ja Borm
https://www.sciencedirect.com/science/article/pii/S0165247817301761
Nanoparticles and targeted drug delivery in cancer therapy. ... Nanoparticles (NPs) are the new identified tools by which we can deliver drugs into tumor cells with minimum drug leakage into normal cells. Conjugation of NPs with ligands of cancer specific tumor biomarkers is a potent therapeutic approach to treat cancer diseases with the high ...Author: Behdokht Bahrami, Behdokht Bahrami, Mohammad Hojjat-Farsangi, Mohammad Hojjat-Farsangi, Hamed Mohamm...
https://www.particle-works.com/applications/targeted-drug-delivery/
Targeted Drug Delivery. Targeted drug delivery is a rapidly developing field within pharmacology. This application involves Active Pharmaceutical Ingredient (API) encapsulation or tethering to nano- or microparticles in order to deliver therapeutic molecules to the malignant site. This is usually undertaken using one of the two targeting ...
https://www.sciencedirect.com/science/article/pii/S1369702105710336
One of the most promising applications for targeted drug delivery using nanoparticles is in local application using interventional procedures such as catheters. Potential applications have focused on intra-arterial drug delivery to localize therapeutic agents in the arterial wall to inhibit restenosis67, 68. Restenosis is the re-obstruction of ...Author: Tarek M. Fahmy, Peter M. Fong, Amit Goyal, W. Mark Saltzman
https://pubs.acs.org/doi/abs/10.1021/acsnano.7b08620
Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells. Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers ACS NanoAuthor: Maria Eleni Kyriazi, Davide Giust, Afaf H. El-Sagheer, Afaf H. El-Sagheer, Peter M. Lackie, Otto L. ...
https://www.understandingnano.com/nanotechnology-drug-delivery.html
Nanotechnology and Nanoparticles in Drug Delivery - Chemotherapy: Researchers are also continuing to look for more effective methods to target nanoparticles carrying therapeutic drugs directly to diseased cells. For example scientists are MIT have demonstrated increased levels of drugs delivery to tumors by using two types of nanoparticles. The ...
https://www.future-science.com/doi/pdfplus/10.4155/tde.15.56
Targeted drug delivery to the brain using magnetic nanoparticles Review in the brain unless provided in much larger doses, as the high lipophilicity leads to a rapid clearance from the circulation and accumulation nonspecifically every-where in the body (cf. [5]). Furthermore, the prominent expression of a number of ATP-binding cassette (ABC)
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