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https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-5-70
Nov 09, 2012 · In parallel to naked TMAs, antibody-drug conjugates (ADCs) have been developed for targeted delivery of potent anti-cancer drugs with the aim of bypassing the morbidity common to conventional chemotherapy.Author: Michael A Firer, Gary Gellerman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · For cancer therapies, the ideal targeted drug delivery system is the one that delivers the drug only to the target tumor. The reality, however, is far away from that ideal scenario. The amount of drug delivered to tumor targets is much less than 5% at most.Author: You Han Bae, Kinam Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819756/
Oct 22, 2013 · It contains 12 papers embracing most aspects of cancer related to the exploration of active targeted nanoparticles for cancer treatment and diagnosis, including the exploitation of novel cancer drug targets, vaccine design against cancer, innovative methods for drug delivery-based on focused ultrasound or convection enhanced delivery, and mathematical modeling as an …Author: Andreas G. Tzakos, Evangelos Briasoulis, Theresia Thalhammer, Walter Jäger, Vasso Apostolopoulos
https://journals.sagepub.com/doi/pdf/10.1177/153303460500400405
specifically targeted drug delivery systems arises from not only the clinical perspective but can also help in eradicating cancer from the patient before it kills the patient.
https://www.ncbi.nlm.nih.gov/pubmed/28760499
It has been shown that conjugation of nanocarriers with molecules such as antibodies and their variable fragments, peptides, nucleic aptamers, vitamins, and carbohydrates can lead to effective targeted drug delivery to cancer cells and thereby cancer attenuation.Author: Behdokht Bahrami, Behdokht Bahrami, Mohammad Hojjat-Farsangi, Mohammad Hojjat-Farsangi, Hamed Mohamm...
https://www.sciencedirect.com/science/article/pii/S136759311000075X
The underlying reason for this has been obtained in pre-clinical biodistribution and pharmacokinetics studies showing that targeted delivery leads to high intratumoral free drug concentrations, while non-target tissues are largely spared from chemotherapeutic exposure.Author: Stephen C Alley, Nicole M Okeley, Peter D Senter
https://www.ncbi.nlm.nih.gov/pubmed/26061298
Nanoparticles as drug delivery system have received much attention in recent years, especially for cancer treatment. In addition to improving the pharmacokinetics of the loaded poorly soluble hydrophobic drugs by solubilizing them in the hydrophobic compartments, nanoparticles allowed cancer specific drug delivery by inherent passive targeting phenomena and adopted active targeting …Author: Preeti Kumari, Balaram Ghosh, Swati Biswas
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Recently, multifunctional QDs have been synthesized, making them a promising targeted drug delivery vehicle for the diagnosis and image-guided chemotherapy of various cancers 25,26.Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet
Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules ("molecular targets") that are involved in the growth, progression, and spread of cancer. Targeted cancer therapies are sometimes called "molecularly targeted drugs…
https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/targeted-therapy/what-is.html
Targeted therapy drugs, like other drugs used to treat cancer, are technically considered chemotherapy. But targeted therapy drugs don’t work the same way as traditional or standard chemotherapy (chemo) drugs. Targeted drugs zero in on some of the changes that make cancer cells different from normal cells.
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