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https://www.sciencedirect.com/science/article/pii/S1818087614000634
Thermoresponsive polymers are used for biomedical applications including drug delivery, tissue engineering and gene delivery , , , , . Temperature-responsive polymers exhibit a volume phase transition at a certain temperature, which causes a sudden change in the solvation state.Author: Arijit Gandhi, Abhijit Paul, Suma Oommen Sen, Kalyan Kumar Sen
https://www.sciencedirect.com/science/article/pii/S0928493119307775
3.1. Drug delivery systems. The synthesis of drug delivery systems is a field where UCST polymers are becoming applied owing to their ability to load lipophilic therapeutics at low temperature and then to release them upon heating [, , ]. In fact, often, there are sharp differences in temperature between two different zones of the body.Author: Mattia Sponchioni, Mattia Sponchioni, Umberto Capasso Palmiero, Davide Moscatelli
https://www.mdpi.com/2073-4360/3/3/1215/htm
Several groups have shown the formation of a novel drug delivery device with magnetic targeting capability by coating a magnetic nanoparticle, conjugated to active drug, with a thermoresponsive polymer. Upon heating above the LCST, the coating shrinks and releases the active drug [149,151,152,155,156].Author: Mark A. Ward, Theoni K. Georgiou
https://link.springer.com/protocol/10.1007%2F978-1-4939-0363-4_4
Feb 03, 2014 · The MG1 particles were subsequently used for protein drug delivery, using BSA as a model. The release profile showed the best fit with the zero-order model. Finally, cytotoxicity studies of the synthesized MG1 and NG1 particles were carried out, using in vitro MTT assay, so as to determine the overall biocompatibility of the materials.Author: Sushil Mishra, Arnab De, Subho Mozumdar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681499/
Jul 12, 2019 · The synthetic thermoresponsive polymers mainly poly(N-isopropylacrylamide) (pNIPAAm) and pluronic F127 (PF127) are widely used for drug delivery applications since they can form gels near the body temperature of 37 °C [35,36,37].Author: Sudipta Chatterjee, Patrick Chi-leung Hui
https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201100252
Many drug delivery systems have been devised to address this problem, including those that show a change in properties in response to a temperature stimulus. In particular, colloidal materials based on thermoresponsive polymers offer a means to transport drugs selectively into tumour tissues that are hyperthermic, either intrinsically or through the application of clinical procedures such as localised …Author: Samer R. Abulateefeh, Samer R. Abulateefeh, Sebastian G. Spain, Jonathan W. Aylott, Weng C. Chan, Ma...
https://web.ics.purdue.edu/~jfleary/nanomedicine_course_2013/Lecture%206/References/Schmaljohann%202006.pdf
the settings of drug delivery but show potential there-fore, will also be discussed. There is a vast number of publications available on this topic, therefore only a selection of examples will be discussed. 2. Thermo-responsive polymers in drug delivery 2.1. Volume phase transitions Ilmain et al. have classified volume phase transi-tions ...
https://www.researchgate.net/publication/257812397_Thermoresponsive_polymers_as_gene_and_drug_delivery_vectors_Architecture_and_mechanism_of_action
In drug delivery technology, the reversible behavior of thermoresponsive copolymers formed by dual hydrophilic segments can be used to facilitate the loading process of a
https://www.mdpi.com/2073-4360/12/3/580
However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications.Author: Xiaomin Xu, Yang Liu, Wenbo Fu, Mingyu Yao, Zhen Ding, Jiaming Xuan, Dongxiang Li, Shengjie Wang, Yo...
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