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https://www.jstor.org/stable/41001780
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Shanta Dhara1, Nagesh Kolishettibc1, Stephen J. Lippardad2, and Omid C. Farokhzadbc2
http://dspace.mit.edu/handle/1721.1/65115
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Author(s) Dhar, Shanta ; Kolishetti, Nagesh ; Lippard, Stephen J. ; Farokhzad, Omid C.
https://ui.adsabs.harvard.edu/abs/2011PNAS..108.1850D/abstract
Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to …
https://www.jstor.org/stable/41001780
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Shanta Dhara1, Nagesh Kolishettibc1, Stephen J. Lippardad2, and Omid C. Farokhzadbc2
https://core.ac.uk/display/8215226
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles . By Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad and Stephen J. Lippard. Abstract. Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its ...
https://www.sciencedirect.com/science/article/pii/S0753332215000864
Trastuzumab is a highly targeting protein to HER2 protein, and it is usually combined with paclitaxel or cisplatin for the treatment of HER2-overexpressing breast cancer. In the present work, we used trastuzumab as a targeting carrier for platinum drug delivery.
https://www.thno.org/v09p6568.htm
Targeted Delivery of Cisplatin-Derived Nanoprecursors via a Biomimetic Yeast Microcapsule for Tumor Therapy by the Oral Route Xing Zhou 1,* , Kaijian Ling 2,* , Mengyu Liu 1,* , Xiangjun Zhang 1 , Jun Ding 3 , Yan Dong 4 , Zhiqing Liang 2 , Jianjun Li 4 , Jianxiang Zhang 1
http://core.ac.uk/display/8522815
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
https://www.researchgate.net/publication/23445480_Dhar_S_Gu_FX_Langer_R_Farokhzad_OC_and_Lippard_SJ_Targeted_delivery_of_cisplatin_to_prostate_cancer_cells_by_aptamer_functionalized_PtIV_prodrug-PLGA-PEG_nanoparticles_Proc_Natl_Acad_Sci_USA_105_17356
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci USA 105: 17356-17361
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.24382
therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer Ping Mu 1 , Shunji Nagahara 2 , Naoki Makita , Yuzo Tarumi 3 , Kenji Kadomatsu 1 and Yoshifumi Takei 1,4 * 1 Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, Japan
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1268-z
Jun 25, 2019 · There is an urgent need for targeted biological therapies for prostate cancer with greater efficacy and less toxicity, particularly for metastatic disease, where current therapies are not curative. Therapeutic adenoviral vectors or oncolytic adenoviruses offer the possibility of a competent, nontoxic therapeutic alternative for prostate cancer.
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Hydrogels are efficient candidates for controlled release, bioadhesive and/or targeted drug delivery as they can encapsulate biomacromolecules, including proteins and DNA, and hydrophilic or hydrophobic drugs 110. Hydrogel-based drug delivery systems can be used in different ways for oral, rectal, ocular, epidermal,...
https://www.researchgate.net/publication/255984579_LHRH-Targeted_Nanogels_as_a_Delivery_System_for_Cisplatin_to_Ovarian_Cancer
Collectively, the LHRH-mediated polysaccharide nanoparticles appeared to be a promising nanomedicine drug delivery system for tumor-targeted delivery of cisplatin.
https://www.sciencedirect.com/science/article/pii/S1549963416301290
In this study we developed a PLGA-PEG NP conjugated to anti-CD24 for targeted delivery of a therapeutic agent and for potential diagnostic imaging options for prostate cancer. We also report the results of using these NPs conjugated to anti-CD24 and encapsulated with docetaxel for enhanced delivery of docetaxel to the prostate tumor site in a ...
https://www.dfhcc.harvard.edu/insider/member-detail/member/omid-c-farokhzad-md/
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A 2008; 105:17356-61. PubMed; Wang AZ,Bagalkot V,Vasilliou CC,Gu F,Alexis F,Zhang L,Shaikh M,Yuet K,Cima MJ,Langer R,Kantoff PW,Bander NH,Jon S,Farokhzad OC. Superparamagnetic iron oxide nanoparticle ...
https://www.nih.gov/news-events/nih-research-matters/chemotherapy-using-nanoparticles
They can carry drug molecules and be targeted to specific cells. Recently, a team of scientists from the Massachusetts Institute of Technology and Brigham and Women's Hospital showed that they could store an inactive form of cisplatin, called a prodrug, inside nanoparticles that are engineered to target a specific protein on prostate cancer cells.
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