Targeted Delivery Of Cisplatin To Prostate Cancer Cells

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Targeted delivery of cisplatin to prostate cancer cells by ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582270/
    Nov 11, 2008 · These results confirm the complete delivery pathway of cisplatin via 1 to PSMA-expressing prostate cancer cells through targeted nanoparticle endocytosis followed by reduction of 1 to deliver a lethal dose of the drug, which forms its signature adduct on nuclear DNA in the cell.Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard

Targeted delivery of cisplatin to prostate cancer cells by ...

    https://www.pnas.org/content/pnas/105/45/17356.full.pdf
    Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV)Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard

Targeted delivery of cisplatin to prostate cancer cells by ...

    https://www.ncbi.nlm.nih.gov/pubmed/18978032
    Nov 11, 2008 · Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Dhar S(1), Gu FX, Langer R, Farokhzad OC, Lippard SJ. Author information: (1)Department of Chemistry, Massachusetts Institute of Technology…Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard

Targeted delivery of cisplatin to prostate cancer cells by ...

    https://miami.pure.elsevier.com/en/publications/targeted-delivery-of-cisplatin-to-prostate-cancer-cells-by-aptame
    title = "Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA - PEG nanoparticles", abstract = "Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its application …Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard

Targeted delivery of cisplatin to prostate cancer cells by ...

    https://ui.adsabs.harvard.edu/abs/2008PNAS..10517356D/abstract
    Nov 01, 2008 · We report a unique strategy to deliver cisplatin to prostate cancer cells by constructing Pt(IV)-encapsulated prostate-specific membrane antigen (PSMA) targeted nanoparticles (NPs) of poly(D,L-lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG…Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard

Targeted delivery of a cisplatin prodrug for safer and ...

    https://www.pnas.org/content/108/5/1850
    Feb 01, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, prostate, and refractory non-Hodgkin’s lymphomas (2, 3).Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad

Targeted delivery of a cisplatin ... - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033286/
    Feb 01, 2011 · Prolonged drug residence in blood following intravenous administration of Pt prodrug-loaded NPs is a prerequisite for the application of the PLGA- b -PEG-NPs in controlled intravenous delivery of cisplatin in the form of a prodrug for prostate cancer treatment.Author: Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, Omid C. Farokhzad

Trastuzumab-cisplatin conjugates for targeted delivery of ...

    https://www.sciencedirect.com/science/article/pii/S0753332215000864
    Trastuzumab is a highly targeting protein to HER2 protein, and it is usually combined with paclitaxel or cisplatin for the treatment of HER2-overexpressing breast cancer. In the present work, we used trastuzumab as a targeting carrier for platinum drug delivery.Author: Rong Huang, Qiucui Wang, Xiangyang Zhang, Jin Zhu, Baiwang Sun

Chemotherapy Using Nanoparticles National Institutes of ...

    https://www.nih.gov/news-events/nih-research-matters/chemotherapy-using-nanoparticles
    They can carry drug molecules and be targeted to specific cells. Recently, a team of scientists from the Massachusetts Institute of Technology and Brigham and Women's Hospital showed that they could store an inactive form of cisplatin, called a prodrug, inside nanoparticles that are engineered to target a specific protein on prostate cancer cells.

Clinical Trials Using Cabozantinib S-malate - cancer.gov

    https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/cabozantinib-s-malate
    Clinical trials are research studies that involve people. The clinical trials on this list are studying Cabozantinib S-malate. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease.

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