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https://www.sciencedirect.com/science/article/pii/S1359644608003309
Drugs targeting brain cancers across the blood–brain barrier: chemical functionalization of therapeutic agents or of nanoparticulate carriers? As previously stated, the limiting factor in the treatment of brain cancers is the delivery of therapeutic agents to the brain across the BBB.Author: Lucienne Juillerat-Jeanneret
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140134/
Dec 01, 2010 · Effective delivery of therapeutic agents into the brain can greatly improve the treatments of neurological and neurodegenerative diseases. Application of focused ultrasound facilitated by microbubbles has shown the potential to deliver drugs across the blood–brain barrier into targeted sites within the brain noninvasively.Author: Cheri X Deng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520542/
Purpose. The blood–brain barrier (BBB) essentially restricts therapeutic drugs from entering into the brain. This study tests the hypothesis that brain endothelial cell derived exosomes can deliver anticancer drug across the BBB for the treatment of brain cancer in a zebrafish (Danio rerio) model.Author: Tianzhi Yang, Paige Martin, Brittany Fogarty, Alison Brown, Kayla Schurman, Roger Phipps, Viravuth P...
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
Modern methods for delivery of drugs across the blood–brain barrier ... Modern methods of transporting drugs across the blood–brain barrier. ... a brain targeted doxorubicin liposomes coated with the tripeptide glutathione at the tips of polyethylene glycol (PEG), is in the Phase I/II clinical trial in the Antoni van Leeuwenhoek hospital ...Author: Yan Chen, Lihong Liu
https://phys.org/news/2018-05-nanoparticles-drugs-blood-brain-barrier-glioblastoma.html
May 24, 2018 · Nanoparticles carrying two drugs can cross the blood-brain barrier and shrink glioblastoma tumors ... with a way to get them across the blood …
https://academic.oup.com/neuro-oncology/article/18/1/27/2509241
Sep 10, 2015 · Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma ... the insufficient spatial distribution of the drug in the brain may restrict targeted delivery to invasive glioma cells 52 and leave the infiltrative growing edge of the tumor and the invasive glioma cells at distant sites untreated ...Author: Rajneet K. Oberoi, Karen E. Parrish, Terence T. Sio, Rajendar K. Mittapalli, William F. Elmquist, Ja...
https://thesis.library.caltech.edu/11033/
Brain metastases of human epidermal growth factor receptor 2 (HER2)-positive breast cancer are presenting an increasing problem in the clinic. While HER2-targeted therapies effectively control systemic disease, their efficacy against brain metastases is hindered by their inability to penetrate the blood-brain and blood-tumor barriers (BBB and BTB).Author: Emily Ann Wyatt
https://www.nature.com/articles/s41598-019-44569-6
Jun 04, 2019 · Next we investigated the effect of surface modification of AuNPs to cross the blood brain barrier by using a co-culture being composed of bEnd.3 brain endothelial cells and astrocyte-like (ALT ...Author: Mattaka Khongkow, Teerapong Yata, Suwimon Boonrungsiman, Uracha Rungsardthong Ruktanonchai, Duncan G...
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