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https://www.researchgate.net/publication/11852803_Targeted_delivery_of_antisense_oligonucleotides_in_cancer
The objective of this study was to investigate the use of folate-targeted liposomes for the delivery of encapsulated oligonucleotides to folate receptor (FR)-positive tumor cells in vitro and in vivo.
https://www.sciencedirect.com/topics/neuroscience/antisense-oligonucleotide
Stanley T. Crooke, in Encyclopedia of Cancer (Second Edition), 2002. Antisense oligonucleotides are used to hybridize to a specific RNA molecule in vivo and thereby to inhibit its subsequent use; in most cases, the target RNA is a messenger RNA (mRNA), which cannot then be translated into a protein. Once the gene sequence of interest is known, an antisense oligonucleotide with the ...
https://www.sciencedirect.com/science/article/pii/S0168365901003121
Inhibition of gene expression by antisense oligonucleotides (asODNs) has become a viable possibility for gene-targeted therapy. Since the basis of this therapy stems from the specificity of Watson–Crick base pairing, this new approach should have increased specificity for neoplastic cells and may reduce the problem of systemic toxicity [1 ...Author: F. Pastorino, D. Stuart, M. Ponzoni, T.M. Allen
https://pubs.acs.org/doi/10.1021/mp060039w
Jul 12, 2006 · Targeting nanocarriers containing antisense oligonucleotides to cancer cell. Journal of Drug Delivery Science and Technology 2017, 37, 97-114. DOI: 10.1016/j.jddst.2016.12.001. Dongkyu Kim, Sook Hee Ku, Hyosuk Kim, Ji Hoon Jeong, Minhyung Lee, …Author: Shyh Dar Li, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117763/
Sep 01, 2014 · Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in miceAuthor: Thazha P. Prakash, Mark J. Graham, Jinghua Yu, Rick Carty, Audrey Low, Alfred Chappell, Karsten Schm...
https://academic.oup.com/nar/article/42/13/8796/1283685
Jul 03, 2014 · Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl ... Walt F. Lima, Shuling Guo, Brett P. Monia, Eric E. Swayze, Punit P. Seth, Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency ... cancer and several rare and orphan disease ...Author: Thazha P. Prakash, Mark J. Graham, Jinghua Yu, Rick Carty, Audrey Low, Alfred Chappell, Karsten Schm...
https://pubs.acs.org/doi/abs/10.1021/acsami.9b20707
Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for co-delivery of chemotherapeutic drug (Dox) and two different antisense oligonucleotides (Bcl2 and P-gp ASOs) into drug-resistant cancer cells for enhanced therapy.Author: Qingshan Pan, Cunpeng Nie, Yanlei Hu, Jintao Yi, Chang Liu, Juan Zhang, Manman He, Mengyun He, Tingt...
https://www.onlinelibrary.wiley.com/doi/full/10.1111/cas.13267
Apr 26, 2017 · Therefore, we developed a combined therapy of microRNA‐21 antisense oligonucleotides (ASO‐miR‐21) and gemcitabine (Gem) using a targeted co‐delivery nanoparticle (NP) carrier and investigated the synergistic inhibitory effects on pancreatic cancer cells metastasis and growth.Author: Yaqing Li, Yinting Chen, Jiajia Li, Zuoquan Zhang, Chumei Huang, Guoda Lian, Kege Yang, Shaojie Chen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664895/
Oligonucleotides including antisense oligonucleotides and siRNA are emerging as promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical to their successful clinical application. Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery.Author: Bo Yu, Xiaobin Zhao, L. James Lee, Robert J. Lee
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