Targeted Biodegradable Nanoparticles For Drug Delivery To Smooth Muscle Cells

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Targeted biodegradable nanoparticles for drug delivery to ...

    https://www.ncbi.nlm.nih.gov/pubmed/22523971
    Targeted biodegradable nanoparticles for drug delivery to smooth muscle cells. Kona S(1), Specht D, Rahimi M, Shah BP, Gilbertson TA, Nguyen KT. Author information: (1)Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.Author: Soujanya Kona, Soujanya Kona, Danyel Specht, Danyel Specht, Maham Rahimi, Maham Rahimi, Bhavik P. Sh...

Biodegradable nanoparticles for drug and gene delivery to ...

    https://www.sciencedirect.com/science/article/pii/S0169409X02002284
    Biodegradable nanoparticles formulated from poly (d,l-lactide-co-glycolide) (PLGA) have been extensively investigated for sustained and targeted/localized delivery of different agents including plasmid DNA, proteins and peptides and low molecular weight compounds.Research about the mechanism of intracellular uptake of nanoparticles, their trafficking and sorting into different intracellular ...Author: Jayanth Panyam, Vinod D Labhasetwar

Drug packaging and delivery using perfluorocarbon ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003007/
    Targeted drug delivery nanoparticles could bind, and the close apposition to the targeted cell membrane may permit enhanced lipid-lipid exchange with the lipid monolayer of the nanoparticle, which propels drugs dissolved in the outer lipid membrane of the nanoparticles into the targeted cells, enhancing the inhibition effect on SMCs.Author: Zhao-xiong Zhou, Bai-gen Zhang, Hao Zhang, Xiao-zhong Huang, Ya-li Hu, Li Sun, Xiao-min Wang, Ji-wei...

Targeted biodegradable nanoparticles for drug delivery to ...

    https://europepmc.org/abstract/MED/22523971
    Feb 01, 2012 · Targeted biodegradable nanoparticles for drug delivery to smooth muscle cells. (PMID:22523971) Abstract Citations ... Targeted delivery of therapeutic agents to prevent smooth muscle cell (SMC) proliferation is important in averting restenosis (a narrowing of blood vessels). ... (human aortic smooth muscle cells) demonstrated that PDGF-BB ...Author: Soujanya Kona, Soujanya Kona, Danyel Specht, Danyel Specht, Maham Rahimi, Maham Rahimi, Bhavik P. Sh...

Targeted Drug Delivery To Human Aortic Smooth Muscle Cells ...

    https://rc.library.uta.edu/uta-ir/handle/10106/1106
    However, their limitations include the inefficient delivery of drugs to inhibit smooth muscle cell proliferation, a major cause of restenosis. Therefore, we propose the use of biodegradable nanoparticles as a drug delivery system for transporting a therapeutic agent to human aortic smooth muscle cells (HASMC) to prevent their proliferation.Author: Danyel Specht

Drug packaging and delivery using perfluorocarbon ...

    https://www.nature.com/articles/aps2009146
    Nov 05, 2009 · Drug packaging and delivery using perfluorocarbon nanoparticles for targeted inhibition of vascular smooth muscle cells Skip to main content Thank you for visiting nature.com.Author: Zhao-xiong Zhou, Bai-gen Zhang, Hao Zhang, Xiao-zhong Huang, Ya-li Hu, Li Sun, Xiao-min Wang, Ji-wei...

Biodegradable nanoparticles for drug delivery and ...

    https://www.sciencedirect.com/science/article/pii/S1359028602001171
    1. Introduction. Polymer nanoparticles are particles of less than 1 μm diameter that are prepared from natural or synthetic polymers. Nanoparticles have become an important area of research in the field of drug delivery because they have the ability to deliver a wide range of drugs to varying areas of the body for sustained periods of time.Author: M.L Hans, A.M Lowman

TARGETED DRUG DELIVERY TO HUMAN AORTIC SMOOTH …

    http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.551
    BibTeX @MISC{Specht08targeteddrug, author = {Danyel Specht and Danyel Specht M. S}, title = {TARGETED DRUG DELIVERY TO HUMAN AORTIC SMOOTH MUSCLE CELLS USING BIODEGRADABLE NANOPARTICLES}, year = {2008}}

Targeted Antiproliferative Drug Delivery to Vascular ...

    https://www.ahajournals.org/doi/10.1161/01.CIR.0000044020.27990.32
    In general, porcine aortic smooth muscle cells grown in Clonetics smooth muscle basal media as previously reported 17 were incubated for 2 days and then exposed to treatments (below) for 30 minutes. Unbound nanoparticles and unabsorbed drug were washed from wells, and cultures were grown to ≈85% confluence (ie, about 3 days).Author: Gregory M. Lanza, Xin Yu, Patrick M. Winter, Dana R. Abendschein, Kerry K. Karukstis, Michael J. Sco...

Targeted Antiproliferative Drug Delivery to Vascular ...

    https://www.ahajournals.org/doi/abs/10.1161/01.cir.0000044020.27990.32
    We have previously demonstrated that tissue factor–targeted nanoparticles can penetrate and bind stretch-activated vascular smooth muscles in the media after balloon injury. In the present study, the concept of VSMC-targeted nanoparticles as a drug-delivery platform for the prevention of restenosis after angioplasty is studied.Author: Gregory M. Lanza, Xin Yu, Patrick M. Winter, Dana R. Abendschein, Kerry K. Karukstis, Michael J. Sco...

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