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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365046/
As systemic clearance of VEGF is rapid and acute, VEGF-induced vascular changes are largely short-lived 28; VEGF coadministration is especially encouraging as a means to enhance systemic gene delivery after intravascular administration of vectors to conscious mammals using a reduced vector dose.Author: Paul Gregorevic, Michael J Blankinship, James M Allen, Robert W Crawford, Leonard Meuse, Daniel G Mi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149982/
Aug 16, 2010 · Between the two major classifications of administration, local vs. systemic, systemic delivery approaches are often preferred due to ease of administration. However, systemic delivery may result in suboptimal drug concentration being achieved in the CNS, and lead to erroneous conclusions regarding agent efficacy.Author: Laura Serwer, Rintaro Hashizume, Tomoko Ozawa, C. David James
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914751
Jan 29, 2020 · Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier. Dr. Hyun Su Min. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, …Author: Hyun Su Min, Hyun Jin Kim, Mitsuru Naito, Satomi Ogura, Kazuko Toh, Kotaro Hayashi, Beob Soo Kim, Sh...
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02917
mRNA therapeutics hold great potential for treating a variety of diseases through protein-replacement, immunomodulation, and gene editing. However, much like siRNA therapy the majority of progress in mRNA delivery has been confined to the liver. Previously, we demonstrated that poly(β-amino esters), a class of degradable polymers, are capable of systemic mRNA delivery to the lungs in mice ...Author: James C. Kaczmarek, Kevin J. Kauffman, Owen S. Fenton, Kaitlyn Sadtler, Asha K. Patel, Michael W. He...
https://medical-dictionary.thefreedictionary.com/systemic
systemic: [ sis-tem´ik ] pertaining to or affecting the body as a whole. systemic disease one affecting a number of tissues that perform a common function.
https://www.onlinelibrary.wiley.com/doi/full/10.1002/adma.201805697
Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Lei Han. Department of Neurosurgery, Tianjin Medical University General Hospital; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin Neurological Institute, Tianjin, 300052 ...Author: Lei Han, Chaoyong Liu, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie...
https://www.sciencedirect.com/science/article/pii/S0142961215010273
However, reports on systemic mRNA delivery are limited, most likely because of technical difficulties , , . A major obstacle for systemic mRNA delivery is the susceptibility of mRNA to enzymatic degradation in physiological environments.Author: Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary, Kaori Mach...
https://www.lawinsider.com/dictionary/systemic-delivery
Systemic Delivery means the administration of a drug product systemically in the body of the patient, including by intravenous, subcutaneous, oral or pulmonary administration. Administration of a drug product to the eye or its adnexa through a Drug Delivery System shall not be deemed to be Systemic …
https://www.sciencedirect.com/science/article/pii/S0168365919306492
Therefore, systemic delivery of AMO-21 may be a useful approach for glioblastoma gene therapy. With the purpose of developing the effects of AMO-21 by systemic administration, T7-exo seemed to be an adequate delivery carrier compared with RVG-exo because it can …Author: Gyeungyun Kim, Minkyung Kim, Youngki Lee, Jung Woo Byun, Do Won Hwang, Minhyung Lee
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