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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmonary administration of peptides and proteins.Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.sciencedirect.com/science/article/pii/0378517388902463
Special considerations are required for the formulation, pharmacokinetic and analytical aspects of peptide/protein drugs. Further work is needed on these aspects and on the routes of administration for commercial viability of therapeutic peptides/proteins.Author: Ajay K. Banga, Yie W. Chien
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
While proteins and peptides have immense therapeutic potential, delivery and systemic stability currently limit their clinical use. The oral route is appealing, as it is a simple and often inexpensive route of delivery.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://www.sciencedirect.com/science/article/abs/pii/0168365994900817
This manuscript reviews data on lung delivery of several peptidic compounds administered for either local or systemic effects. Leuprolide, a non-apeptide and analog of LH-RH is used as a model drug for those peptides administered via lung for a systemic pharmacological effect.Author: A. Adjei, P. Gupta
https://www.atsjournals.org/doi/full/10.1513/pats.200409-049TA
Dec 01, 2004 · No noninvasive route of drug delivery provides the bioavailability of the pulmonary epithelium. The lungs are far more permeable to macromolecules than any other portal of entry into the body ().Some of the most promising therapeutic agents are peptides and proteins, which could be inhaled instead of injected, thereby improving compliance.Author: John S. Patton, C. Simone Fishburn, Jeffry G. Weers
https://www.researchgate.net/publication/305636118_Carrier_Mediated_Systemic_Delivery_of_Protein_and_Peptide_Therapeutics
Although a vast number of studies are dealing with novel drug delivery systems, till now only a handful of controlled release formulations for proteins and peptides have been approved by FDA.
https://www.researchgate.net/publication/11666098_The_lung_as_a_route_for_systemic_delivery_of_the_therapeutic_proteins
The lung as a route for systemic delivery of the therapeutic proteins.pdf. ... Sayani AP, Chien YW: Systemic delivery of peptides and pro-teins across absorptive mucosae.
https://www.intechopen.com/books/smart-drug-delivery-system/noninvasive-strategies-for-systemic-delivery-of-therapeutic-proteins-prospects-and-challenges
It is well established that proteins have great physiological importance, thus possessing great potential for therapeutic use. There is increased interest in protein/peptide pharmaceuticals delivery due to recent improvements in analytical methods, advancements in molecular biology and genetic engineering, and a better understanding of regulatory roles of proteins and peptides. There are ...Author: Tiam Feridooni, Adam Hotchkiss, Remigius U. Agu
http://www.eurekaselect.com/144103/article
Keywords:Drug delivery system, control release, sustain release, systemic delivery, protein and peptide therapeutic, route of administration, insulin. Abstract:Over the last few decades proteins and peptide therapeutics have occupied an enormous fraction of pharmaceutical industry. Despite their high potential as therapeutics, the big challenge ...Author: Rahela Zaman, Iekhan Othman, Ezharul Hoque Chowdhury
http://www.globalresearchonline.net/journalcontents/v12-1/007.pdf
macromolecular proteins are often recognized as “foreign” by the body, which may respond with the production of a specific antibody. Parenteral drug delivery mainly consists of three major routes - IV, IM & SC. Currently method of choice for parenteral systemic …
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