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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410909/
Apr 17, 2015 · Several chassis have been used for synthetic drug delivery, including bacteriophage, 1,2 bacteria, bacteria-derived lipid vesicles, 3 and eukaryotic cells. 4 In this review, we focus on the current state of the art in applications with bacterial chassis as we believe this holds much promise for the development of microbiota-derived therapeutics.Author: Jan Claesen, Michael A. Fischbach
https://pubs.acs.org/doi/10.1021/sb500258b
The construction of cell therapy systems for use in human medicine is an important emerging subfield within this context. Several chassis have been used for synthetic drug delivery, including bacteriophage, bacteria, bacteria-derived lipid vesicles, and eukaryotic cells.Author: Jan Claesen, Michael A. Fischbach
https://www.researchgate.net/publication/264391357_Synthetic_Microbes_As_Drug_Delivery_Systems
Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of ...
https://pubs.acs.org/doi/abs/10.1021/sb500258b
Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of diagnosing disease, producing and delivering therapeutics, and controlling their numbers to meet containment and safety concerns. A thorough understanding of the microbial ecology of the human body and ...Author: Jan Claesen, Michael A. Fischbach
https://www.nature.com/articles/nature18915
Jul 20, 2016 · A synthetic genetic circuit that mimics the quorum-sensing systems used by bacterial populations to coordinate gene expression enables bacteria to deliver drugs to …Author: Shibin Zhou
https://www.nature.com/articles/nature25021
The mammalian microbiome has many important roles in health and disease 1,2, and genetic engineering is enabling the development of microbial therapeutics and diagnostics 3,4,5,6,7.A key ...Author: Raymond W. Bourdeau, Audrey Lee-Gosselin, Anupama Lakshmanan, Arash Farhadi, Sripriya Ravindra Kumar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675648/
Dec 03, 2015 · Synthetic biology (SB) is an emerging discipline, which is slowly reorienting the field of drug discovery. For thousands of years, living organisms such as plants were the major source of human medicines. The difficulty in resynthesizing natural products, however, often turned pharmaceutical industries away from this rich source for human medicine.Author: Jean-Yves Trosset, Pablo Carbonell
https://www.sciencedirect.com/science/article/pii/S0167779918302580
Chassis including eukaryotic cells, bacteriophages, and bacteria have been used as drug delivery systems; so far, probiotic bacteria have made the best chassis for living therapeutics . Most current work focuses on the gut microbiome for engineering living therapeutics.Author: Danielle B. Pedrolli, Nathan V. Ribeiro, Patrick N. Squizato, Victor N. de Jesus, Daniel A. Cozetto,...
https://core.ac.uk/display/104932564
Synthetic Microbes As Drug Delivery Systems . By Jan Claesen and Michael A. Fischbach. Abstract. ABSTRACT: Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of diagnosing disease, producing and delivering ...Author: Jan Claesen and Michael A. Fischbach
https://www.researchgate.net/publication/305452436_Synthetic_biology_Bacteria_synchronized_for_drug_delivery
Oral drug delivery remains the most preferred approach due to its multiple advantages. Recently there has been increasing interest in the development of advanced vehicles for oral delivery of ...Author: Shibin Zhou
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