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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456838/
The implication for surfactant delivery is that a slow rate of ventilation could result in nonhomogeneous surfactant distribution. This is not the desired outcome because it may inflate parts of the lung receiving surfactant, resulting in lung injury. ALVEOLAR RECRUITMENT.Author: Nina Nouraeyan, Alicia Lambrinakos-Raymond, Marisa Leone, Guilherme Sant’Anna
https://uichildrens.org/health-library/guidelines-surfactant-administration-surfactant-replacement-therapy
Etiology of surfactant inactivation or dysfunction: pulmonary hemorrhage, sepsis, pneumonia, meconium aspiration, and post surfactant slump. Surfactant replacement therapy for RDS - Early rescue therapy should be practiced: First dose needs to be given as soon as diagnosis of RDS is made. RDS in a premature infant is defined as respiratory distress requiring more than 30% oxygen delivered by ...
https://pediatrics.aappublications.org/content/133/1/156
Jan 01, 2014 · Prophylactic Versus Rescue Surfactant. A prophylactic, or preventive, surfactant strategy is defined as intubation and surfactant administration to infants at high risk of developing RDS for the primary purpose of preventing worsening RDS rather than treatment of established RDS; this has been operationalized in clinical studies as surfactant administration in the delivery room before initial ...Author: Richard A. Polin, Waldemar A. Carlo, Newborn
https://www.sciencedirect.com/science/article/pii/S0168365918305832
Pulmonary surfactant and drug delivery. The alveoli are lined by a thin layer of epithelial cells (0.1–0.4 μm), are well vascularized and overall constitute a large surface area (~100 m 2). These properties explain extensive absorption of small molecular drugs with sufficient permeability across the air-blood barrier following pulmonary ...Author: Roberta Guagliardo, Jesús Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840129/
Instillation of surfactant delivery at a slow rate of ventilation could result in a non-homogeneous surfactant distribution. This could lead to over-inflation of only parts of the lung receiving the surfactant while other alveoli remain collapsed. Over-inflation of the alveoli can cause injury resulting in BPD.Author: Nashwa El-Gendy, Anubhav Kaviratna, Cory Berkland, Prajnaparamita Dhar
https://fn.bmj.com/content/104/6/F655
Nov 01, 2019 · The current technology still demands laryngoscopy with all its unpleasant effects for infants. Therefore, studies with pharyngeal surfactant deposition immediately after delivery, the use of laryngeal airways for surfactant administration and attempts to nebulise surfactant are under way.Author: Egbert Herting, Christoph Härtel, Wolfgang Göpel
https://www.sciencedirect.com/science/article/pii/B978032354605800012X
As fewer preterm infants are managed with an endotracheal tube in early life, the usual conduit for surfactant delivery is lacking. With this approach has come a dilemma regarding how and when to deliver surfactant to those showing features of surfactant-deficient respiratory distress syndrome (RDS).Author: Peter A. Dargaville
https://clinicaltrials.gov/ct2/show/NCT01042600
Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
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