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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456838/
Surfactant has revolutionized the treatment of respiratory distress syndrome and some other respiratory conditions that affect the fragile neonatal lung. Despite its widespread use, the optimal method of surfactant administration in preterm infants has yet to be clearly determined.Author: Nina Nouraeyan, Alicia Lambrinakos-Raymond, Marisa Leone, Guilherme Sant’Anna
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840129/
Lung surfactant is crucial for optimal pulmonary function throughout life. An absence or deficiency of surfactant can affect the surfactant pool leading to respiratory distress. Even if the coupling between surfactant dysfunction and the underlying disease ...Author: Nashwa El-Gendy, Anubhav Kaviratna, Cory Berkland, Prajnaparamita Dhar
https://pediatrics.aappublications.org/content/133/1/156
Jan 01, 2014 · Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in preterm infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. Secondary surfactant deficiency also contributes to acute respiratory morbidity in late-preterm and term neonates with meconium aspiration syndrome, pneumonia/sepsis, and perhaps ...Author: Richard A. Polin, Waldemar A. Carlo, Newborn
https://www.hindawi.com/journals/ecam/2015/540916/
The objective of this study was to formulate optimal formulations of microemulsions (MEs) and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Oil-in-water MEs were formulated using surfactant (S) PEG-8 caprylic/capric glycerides and cosurfactant (CoS) polyglyceryl-6-isostearate. Ethyl oleate was used as an oily phase.Author: Vaida Juškaitė, Kristina Ramanauskienė, Vitalis Briedis
https://uichildrens.org/health-library/guidelines-surfactant-administration-surfactant-replacement-therapy
Etiology of surfactant inactivation or dysfunction: pulmonary hemorrhage, sepsis, pneumonia, meconium aspiration, and post surfactant slump. Surfactant replacement therapy for RDS - Early rescue therapy should be practiced: First dose needs to be given as soon as diagnosis of RDS is made. RDS in a premature infant is defined as respiratory distress requiring more than 30% oxygen delivered by ...
https://www.sciencedirect.com/science/article/pii/B978032354605800012X
As fewer preterm infants are managed with an endotracheal tube in early life, the usual conduit for surfactant delivery is lacking. With this approach has come a dilemma regarding how and when to deliver surfactant to those showing features of surfactant-deficient respiratory distress syndrome (RDS).Author: Peter A. Dargaville
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