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https://www.sciencedirect.com/science/article/pii/S0022354916330271
Conceptually, the generation and stabilization of intraluminal supersaturation provide an efficient solution for the growing problem of solubility-limited oral bioavailability. Hence, it is not surprising to see a rapidly increasing number of reports on supersaturating drug delivery systems in recent years.Author: Joachim Brouwers, Marcus E Brewster, Patrick Augustijns
https://www.ncbi.nlm.nih.gov/pubmed/19373886
The configuration of supersaturating drug delivery systems (SDDS) is a promising concept to obtain adequate oral bioavailability. SDDS contain the drug in a high energy or otherwise rapidly dissolving form such that intraluminal concentrations above the saturation solubility of the drug are generated.Author: Joachim Brouwers, Marcus E Brewster, Patrick Augustijns
https://www.researchgate.net/publication/24284694_Supersaturating_Drug_Delivery_Systems_The_Answer_to_Solubility-Limited_Oral_Bioavailability
One way to increase the free drug concentration is to use supersaturating drug delivery systems ( Brouwers et al., 2009). A drug is supersaturated, if its apparent concentration exceeds the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292421/
Feb 23, 2012 · Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system. Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, ... Augustijns P. Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?
https://link.springer.com/article/10.1007/s12272-013-0011-z
Jan 17, 2013 · A supersaturating self-emulsifying drug delivery system (S-SEDDS) was prepared and evaluated for enhanced dissolution of celecoxib (CXB), a poorly water-soluble drug. The selected CXB-dissolved SEDDS formulation consisting 10 % Capryol 90 (oil), 45 % Tween 20 (surfactant), and 45 % Tetraglycol (cosurfactant) had the characteristics of small droplet size and great solubility as 208 nm …Author: Woo Heon Song, Jong Hyeok Park, Dong Woo Yeom, Byeong Kil Ahn, Kyung Min Lee, Sang Gon Lee, Hye Seun...
https://link.springer.com/content/pdf/10.1007%2Fs12272-013-0202-7.pdf
Jul 13, 2013 · In order to characterize the in situ intestinal permeability and in vivo oral bioavailability of celecoxib (CXB), a poorly water-soluble cyclooxygenase (COX)-2 inhibitor, various formulations including the self-emulsifying drug delivery system (SEDDS) and supersaturating SEDDS (S …Author: Woo Heon Song, Dong Woo Yeom, Dong Hoon Lee, Kyung Min Lee, Hyun Joon Yoo, Bo Ram Chae, Seh Hyon Son...
https://www.researchgate.net/publication/234158045_Enhanced_dissolution_of_celecoxib_by_supersaturating_self-emulsifying_drug_delivery_system_S-SEDDS_formulation
A supersaturating self-emulsifying drug delivery system (S-SEDDS) was prepared and evaluated for enhanced dissolution of celecoxib (CXB), a poorly water-soluble drug.
https://www.sciencedirect.com/science/article/pii/S0022354916413274
With recent advances in the development of supersaturating oral dosage forms for poorly water-soluble drugs, pharmaceutical scientists are increasingly applying in vitro dissolution testing under non-sink conditions for a direct evaluation of their ability to generate and maintain supersaturation as a predictive surrogate for ensuring product quality and in vivo performance.Author: Dajun D. Sun, Hong Wen, Lynne S. Taylor
https://www.future-science.com/doi/10.4155/tde.14.116
Apr 08, 2015 · Representative supersaturatable dosage forms include amorphous solid dispersions, nanocrystal formulations and self-(micro)emulsifying drug delivery systems. This review describes the characteristics of these formulations, with emphasis on the suitability of the candidates for each type of formulation, from a physicochemical viewpoint.Author: Kohsaku Kawakami
http://www.bioavailability.com/solubility.html
Strategies for Improving Bioavailability Through Drug Solubility Enhancement. Since drugs must be soluble to achieve GI tract absorption, the majority of drug modification and formulation strategies focus on improving solubility.
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