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https://www.researchgate.net/publication/6241597_Strategies_to_Improve_Drug_Delivery_Across_the_Blood-Brain_Barrier
Strategies to Improve Drug Delivery Across the Blood-Brain Barrier 567 ver, attachment of a targeting ligand (such as trans- and increasing targeting efficiency (by application of selective ...
https://experts.umn.edu/en/publications/strategies-to-improve-delivery-of-anticancer-drugs-across-the-blo
TY - JOUR. T1 - Strategies to improve delivery of anticancer drugs across the blood-brain barrier to treat glioblastoma. AU - Oberoi, Rajneet K.
https://www.tandfonline.com/doi/abs/10.1517/17425247.3.3.419
The development of drugs that act in the CNS has been significantly impeded by the difficulty of delivering them across the blood–brain barrier (BBB). This article aims to provide the reader with a critical overview of important issues in the discovery and development of drugs that need to enter the brain to elicit pharmacological activity, focusing particularly on i) the role of drug ...
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
In the human brain, this fluid volume is approximately 140 mL which is produced and excreted in blood every 4-5 hours. Therefore, the injected drug eventually reaches to the systemic blood circulation and then diffuses to the brain parenchyma following transport across the BBB. Convection –Enhanced delivery
https://www.mdpi.com/1999-4923/11/5/245
In this review, we focused on established and emerging strategies to overcome the blood-brain barrier to increase drug delivery for brain cancer. To date, there are three broad strategies being investigated to cross the brain vascular wall and they are conceived to breach, bypass, and negotiate the access to the nervous tissue.
https://www.medscape.com/viewarticle/770396_5
Nanotechnology may be the key to opening the gate of the blood brain-barrier, providing a significant advantage over currently used drug delivery strategies for brain cancers and other CNS disorders.
http://www.eurekaselect.com/62429
A brief review of the nature of the blood-brain barrier and its transport mechanisms is provided. Strategies to target and improve transport across the blood-brain barrier include the prodrug-lipidisation approach, sequential metabolism chemical delivery systems, drug …
https://www.sciencedirect.com/science/article/pii/S0169409X19302388
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper, reflecting the unique requirements of the brain. In this review, following a brief historical overview of how the concepts of the BBB and the neurovascular unit (NVU) developed, we describe its physiology and architecture, which pose a particular challenge to therapeutic intervention.
https://www.slideshare.net/sayedasalma/brain-specific-delivery
Jul 24, 2018 · • Drug delivery to the brain is the process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain maladies. • This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the Blood Brain Barrier.
https://www.news-medical.net/news/20191202/Strategies-for-improving-drug-delivery-to-treat-brain-tumors.aspx
Despite improvements in drug delivery mechanisms, treating brain tumors has remained challenging. ... integrity of the blood brain barrier -- a specialized vessel wall evolved to keep the brain ...
https://www.slideshare.net/VARSHAAWASAR/brain-targeted-drug-delivery-system
Aug 04, 2014 · -To study the Blood – Brain barrier. -To study different approaches to bypass the BBB and to deliver therapeutics into the brain. 3AWASARKAR VARSHA V. 4. INTRODUCTION • Drug delivery to the brain is the process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain maladies.
https://www.europeanpharmaceuticalreview.com/news/107345/strategies-improving-drug-delivery-brain-tumour-treatment/
Dec 03, 2019 · Scientists from the Georgia Institute of Technology, US have proposed two new strategies for improving the delivery of therapeutic agents for brain tumours. “For a bloodborne therapeutic agent to be effective, it must cross the blood vessel wall to reach cancer cells in adequate quantities,” said Costas Arvanitis, who led the study.“However, tumours can thwart their effectiveness …
https://en.wikipedia.org/wiki/Drug_Delivery_to_the_Brain
Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier for the purpose of treating brain maladies. This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier.
https://www.hindawi.com/journals/isrn/2013/238428/
The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier (BBB) regulating its homeostasis. BBB is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted number of macromolecules from the blood to the brain, protecting it from injuries and ...
https://en.wikipedia.org/wiki/Nanoparticles_for_drug_delivery_to_the_brain
Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood–brain barrier (BBB) using nanoparticles.These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders.
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