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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493051/
Improved drug delivery stands to enhance existing treatments, mediate tumor recurrence, and provide an opportunity to therapeutically target tumors not amenable to resection. Thus, the motivation to enhance drug delivery is powerful and has led to the development of diverse methodologies to target and evade the BBB.Author: Tej D. Azad, James Pan, Ian D. Connolly, Austin Remington, Christy M. Wilson, Gerald A. Grant
https://link.springer.com/article/10.2165%2F00003088-200746070-00002
Oct 18, 2012 · The blood-brain barrier (BBB), together with the blood-cerebrospinal-fluid barrier, protects and regulates the homeostasis of the brain. However, these bar As a result, various drug delivery and targeting strategies are currently being developed to enhance the transport and distribution of drugs into the brain.Author: Albertus G. de Boer, Pieter J. Gaillard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900538/
Strategies for delivery of therapeutics across the blood-brain barrier include osmotic/chemical disruption, enhanced transcytosis (e.g. receptor-mediated mechanisms), nanoparticles/nanotubes, cell-mediated delivery, and ultrasound-mediated BBB opening.Author: David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Fre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572140/
May 24, 2019 · In this review, we focused on established and emerging strategies to overcome the blood-brain barrier to increase drug delivery for brain cancer. To date, there are three broad strategies being investigated to cross the brain vascular wall and they are conceived to breach, bypass, and negotiate the access to the nervous tissue.Author: Alessandro Parodi, Magdalena Rudzińska, Andrei A. Deviatkin, Surinder M. Soond, Alexey V. Baldin, An...
https://www.researchgate.net/publication/6241597_Strategies_to_Improve_Drug_Delivery_Across_the_Blood-Brain_Barrier
barrier for global drug delivery to the brain. In this such as tight junctions, which prevent paracellular. review, we therefore focus on the BBB as the main transport of small and large (water-soluble) com-. barrier for drug transport to the brain.
https://academic.oup.com/neuro-oncology/article/18/1/27/2509241
Sep 10, 2015 · Strategies to Improve Drug Delivery to GBM. Penetration of drugs through the BBB, like other membranes in the body, occurs by 3 major mechanisms: passive diffusion, endocytosis, and carrier-mediated transport. These mechanisms can be exploited in various ways to enhance penetration of drugs into the brain.Author: Rajneet K. Oberoi, Karen E. Parrish, Terence T. Sio, Rajendar K. Mittapalli, William F. Elmquist, Ja...
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