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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.researchgate.net/publication/44591939_Strategies_for_In_Vivo_Delivery_of_siRNAs
Electroporation-based siRNA delivery is an upcoming therapeutic tool to deliver various siRNAs, both in vitro and in vivo. Discussed in this chapter is the review of various successful deliveries ...
https://link.springer.com/article/10.2165/11534450-000000000-00000
Aug 15, 2012 · Delivery strategies can be categorized into physical methods, conjugation methods, and drug delivery system carrier-mediated methods. Physical techniques can enhance siRNA uptake at a specific tissue site using electroporation, pressure, mechanical massage, etc. Terminal modification of siRNAs can enhance their resistance to degradation by ...Author: Yuriko Higuchi, Shigeru Kawakami, Mitsuru Hashida
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441031/
Schematic of strategies for targeted in vivo siRNA delivery. Essentially, these delivery vehicles comprise a targeting and a cargo moiety. In a liposome-based delivery vehicle (a), the siRNA is encapsulated within the aqueous core of a uni- or multi-lamellar...Author: Sang-Soo Kim, Himanshu Garg, Anjali Joshi, N. Manjunath
https://www.sciencedirect.com/science/article/pii/S0169409X16301521
In order to develop siRNAs as therapeutic agents for cancer treatment, delivery strategies for siRNA must be carefully designed and potential gene targets carefully selected for optimal anti-cancer effects. In this review, various modifications and delivery strategies for siRNA delivery are discussed.Author: So Jin Lee, So Jin Lee, Min Ju Kim, Min Ju Kim, Min Ju Kim, Ick Chan Kwon, Ick Chan Kwon, Thomas M. ...
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(09)00151-8
Nov 01, 2009 · Because the main goal of in vivo delivery is to have intact and active siRNAs delivered to the cytoplasm of target cells, the stability of siRNA in the extracellular and intracellular environments is crucial. Naked siRNAs have a very short half-life of a few minutes in serum owing to degradation by ribonucleases (RNAses), rapid renal excretion ...Author: Sang-Soo Kim, Himanshu Garg, Anjali Joshi, N. Manjunath
https://www.researchgate.net/publication/38027227_Strategies_for_targeted_nonviral_delivery_of_siRNAs_in_vivo
Strategies for targeted nonviral delivery of siRNAs in vivo Article · Literature Review in Trends in Molecular Medicine 15(11):491-500 · October 2009 with 567 Reads How we measure 'reads'
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